Mindfulness therapy, a psychological approach emphasizing awareness of the present experience without judgment, has gained attention as a potential intervention for improving the quality of life of patients with autoimmune diseases in Indonesia. With the increasing prevalence of autoimmune diseases and their associated physical and psychological symptoms, mindfulness therapy is highly relevant. This review explored the mechanisms of action, case studies, challenges, and recommendations for implementing mindfulness therapy in Indonesia. Mindfulness has been shown to modulate brain activity associated with emotional processing, reduce inflammation, improve pain management, enhance social relationships, and improve sleep quality. Case studies in Indonesia have demonstrated the effectiveness of mindfulness therapy in patients with rheumatoid arthritis and lupus, with participants reporting significant improvements in their physical and mental symptoms. However, challenges such as insufficient understanding among medical personnel, societal stigma, limited availability of programs, cultural factors, and lack of comprehensive research need to be addressed. Recommendations include enhanced education and training for medical personnel, public awareness initiatives, the development of culturally appropriate programs, improved accessibility, and further research on the effectiveness of mindfulness therapy in Indonesia. By addressing these challenges and implementing recommendations, mindfulness therapy can be effectively integrated into the Indonesian healthcare system to improve patient's quality of life with autoimmune diseases.

Introduction: GSK3, a multifunctional serine/threonine kinase regulates cell-cycle progression, differentiation and apoptosis and its inhibition can have a tumor suppressor/promoter effect, depending on the cell type. There are conflicting reports of GSK3 in cell growth, but most studies have focused on GSK3β and very few on GSK3α in cancer. GSK3α regulates proliferation of melanoma and pancreatic and colon cancer cells, but the predictive role of GSK3A is not known in colon cancer. Material and methods: The prognostic role of GSK3A was assessed in colon cancer patients employing Kaplan-Meier plotter (KM plotter) database. Online ROC plotter tool was used to compare the GSK3A gene expression in colorectal cancer patients receiving any form of chemotherapy. Results: Current results show that higher GSK3A mRNA expression is significantly related to poorer Relapse Free Survival (RFS) in colon cancer patients. Assessment of GSK3A mRNA for different clinicopathological features like clinical stages, TP53 mutation, stage T and stage N highlighted the critical prognostic value of GSK3A mRNA in colon cancer. Discussion and conclusion: GSK3A will help to better predict colon cancer prognosis and to develop better treatment strategies for colon cancer patients and will be beneficial in combating the heterogeneity and complexity of colon cancer.