Impact of Gut Microbiota on Immune System Regulation: A Narrative Review-Scilight

Trends in Immunotherapy

Review

Impact of Gut Microbiota on Immune System Regulation: A Narrative Review

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https://doi.org/10.54963/ti.v9i3.1018
Turdubaev Kursanbek Tashbolotovich, Hazim Abdul Rahman Alhiti, Zaid Khaled, Ridha Jawad Kadhim Albasri, Ahmad Sabah, & Azhimamatova Rakhima. (2025). Impact of Gut Microbiota on Immune System Regulation: A Narrative Review. Trends in Immunotherapy, 9(3), 30–46. https://doi.org/10.54963/ti.v9i3.1018
Volume 9 Issue 3 (September 2025) (in progress)
Copyright (c) 2025 Turdubaev Kursanbek Tashbolotovich, Hazim Abdul Rahman Alhiti, Zaid Khaled, Ridha Jawad Kadhim Albasri, Ahmad Sabah, Azhimamatova Rakhima
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Authors

  • Turdubaev Kursanbek Tashbolotovich

    Medical Faculty, Osh State University, Osh 723500, Kyrgyzstan
  • Hazim Abdul Rahman Alhiti

    Department of Medical Laboratory Analysis, Al Mansour University College, Baghdad 10067, Iraq
  • Zaid Khaled

    Department of Medical Laboratory Analysis, Al‑Turath University, Baghdad 10013, Iraq
  • Ridha Jawad Kadhim Albasri

    Department of Medical Laboratory Analysis, Al‑Rafidain University College, Baghdad 10064, Ira
  • Ahmad Sabah

    Department of Medical Laboratory Analysis, Madenat Alelem University College, Baghdad 10006, Iraq
  • Azhimamatova Rakhima

    International International Medical Faculty, Osh State University, Osh 723500, Kyrgyzstan

Received: 13 February 2025; Revised: 3 March 2025; Accepted: 4 March 2025; Published: 22 July 2025

The microbiota plays an essential role in the regulation of the natural immune system, influencing both innate and adaptive immunological responses. This review extracted information from available observational studies that explore the intricate cooperation between gut microbiota and immune system regulation across various health conditions, including Crohn’s disease, respiratory infections, autoimmune diseases, cancer, metabolic disorders, and infectious diseases. Key findings highlight how dysbiosis, a rotation in the microbiome composition or microbial imbalance, contributes to disease pathogenesis and immune dysregulation, while specific microbial taxa and their metabolites can serve as potential biomarkers and therapeutic targets. By analyzing these studies, the paper aims to provide a comprehensive understanding of the gut microbiota’s impact on immune function and its potential implications for disease prevention and management. In conclusion, this review comprehensively elucidates the complex relationship between gut flora and immune system regulation across various health conditions. The synthesized findings underscore the profound impact of microbiota composition on immune responses, from influencing disease susceptibility and severity to potential therapeutic interventions. Key insights include the identification of microbiota-based biomarkers for predicting treatment outcomes and disease risks, highlighting the potential for personalized medicine approaches. However, the few available observational studies, such as study design variability and the complex nature of microbiota dynamics, necessitate further mechanistic research to validate causal relationships and optimize clinical applications. Moving forward, integrating microbiota-targeted therapies and dietary interventions tailored to individual microbial profiles holds promise for mitigating immune dysregulation and improving overall health outcomes.

Keywords:

Autoimmune; Cytokine; Microbiota; Mucosal immunity

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