This study enrolled 120 patients undergoing elective abdominal or orthopedic surgery (aged 18–75 years, ASA classification I-III) and employed a prospective randomized controlled design to evaluate the effects of regional anesthesia (RA group, n = 60) versus general anesthesia (GA group, n = 60) on perioperative neuro-immune regulation. Through systematic assessment of perioperative cytokine pr...

Spray-dried plasma (SDP), a byproduct of the meatpacking industry, is commonly used in swine diets to enhance growth and optimize feed utilization. Multiple studies have shown that animals' immune responses can be improved by giving them plasma proteins like SDP orally. This study aims to highlight the importance of non-invasive dietary interventions in stimulating immune responses and enhancin...

Immune cell engineering is a cutting-edge strategy in modern immunotherapy, enabling precise, personalized treatments using modified immune cells such as CAR-T and NK cells. This paper introduces an Intelligent Optimized Machine Learning (IoML) framework with Sorting Slap Swarm Optimization (SSSO) to enhance immune cell design. The IoML model employs a ranking-based Deep Neural Network (DNN) to...

Allergic diseases are thought to be caused by a combination of acquired immune activation, excessive activation of innate immunity, and disruption of epithelial barrier function due to scratching, proteases, and more. The removal and inactivation of allergy-related substances in indoor environments are considered effective for reducing allergic disease symptoms. The typical allergens in Japan a...

Only some primary immunodeficiencies are often found in the population, characterized by a mild clinical phenotype and creating a significant burden on society, so-called primary minor immunodeficiencies (PMD). The study aims to create a clinical and laboratory classification of PMD in humans for basic science and practical medicine. A systematic review of scientific publications in PubMed (MED...

Hair loss still frustrates patients and doctors alike because available treatments yield only modest results; accordingly, researchers are pursuing fresh approaches that target the disorder at its biological roots. The study reported here examined how exosome-based immune tuning affects hair regrowth in mouse models and in ex vivo human follicle cultures. When delivered to skin in the ...

Periodontitis is a chronic, progressive inflammatory disease characterized by the gradual destruction of the supporting structures of the teeth, including the periodontal ligament and alveolar bone. This condition primarily originates from microbial dysbiosis in the oral cavity, further influenced by the host’s immune responses and a variety of environmental and behavioral factors. As the leadi...

This study aims to demonstrate the significance of employing non-invasive dietary intervention to control the diversity and abundance of bacterial communities in feces. The indexing databases Scopus, PubMed/Medline, ISI Web of Science, Embase, Cochrane Central, and CINAHL were extensively searched.  Only 13 of 541 papers found in the initial searches met the criteria. Seven studies involving 21...

Considering what was said about Heat Shock Proteins (HSPs) role in the presentation of tumor antigens, today, before using tumor cell extracts as antigens in vaccine preparation, researchers try to increase the efficiency of antigen presentation by APCs via inducing these proteins; however, since different cell lines express different amounts of HSPs under the influence of different temperature...

This study assessed the effect of probiotic supplementation on immune response in physically active males before and after exhausting exercise. With growing evidence linking gut health to immune function, the aim was to determine whether 12 weeks of probiotics could influence key immune markers in athletes. In this semi-experimental study, 28 male athletes (18–35 years) from sports centers in O...