Immunotherapy in Patients With Allergic Asthma and Chronic Allergic Rhinitis: A Retrospective Cohort

Trends in Immunotherapy

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Immunotherapy in Patients With Allergic Asthma and Chronic Allergic Rhinitis: A Retrospective Cohort

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https://doi.org/10.54963/ti.v9i4.1025
Aziza, S., Jassim, A. M., Mohammed, S. A., Mohammed, S. S., Nassar, W., & Siddiqui, M. F. (2025). Immunotherapy in Patients With Allergic Asthma and Chronic Allergic Rhinitis: A Retrospective Cohort. Trends in Immunotherapy, 9(4), 14–24. https://doi.org/10.54963/ti.v9i4.1025
Volume 9 Issue 4 (December 2025): In Progress
Copyright (c) 2025 Seitova Aziza, Ahmed Mahdi Jassim, Sura Akram Mohammed, Samer Shukur Mohammed, Waleed Nassar, Mohd Faizan Siddiqui
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Authors

  • Seitova Aziza

    Pathology, Basic and Clinical Pharmacology Department, International Medical Faculty, Osh State University, Osh City 723510, Kyrgyzstan
  • Ahmed Mahdi Jassim

    Department of Medical Laboratory Analysis, Al Mansour University College, Baghdad 10067, Iraq
  • Sura Akram Mohammed

    Department of Medical Laboratory Analysis, Al-Turath University, Baghdad 10013, Iraq
  • Samer Shukur Mohammed

    Department of Medical Laboratory Analysis, Al-Rafidain University College Baghdad 10064, Iraq
  • Waleed Nassar

    Department of Medical Laboratory Analysis, Madenat Alelem University College Baghdad 10006, Iraq
  • Mohd Faizan Siddiqui

    Department of Public Health, International Medical Faculty, Osh State University, Osh City, 723510, Kyrgyzstan

Received: 15 February 2025; Revised: 19 March 2025; Accepted: 09 April 2025; Published: 09 October 2025

Asthma and allergies both cause similar signs and symptoms and often occur together. Evidence for the effectiveness of immunotherapy has rapidly increased in recent years. Several well-designed studies have demonstrated that allergen immunotherapy may prevent the development of asthma in people with allergic rhinitis. The present study aimed to assess the effect of subcutaneous immunotherapy with specific allergens on clinical symptoms, immunological factors, and cytokines in patients with allergic rhinitis and allergic asthma from the Kyrgyz Republic. This retrospective cohort study was conducted on patients with a slight to moderate level of persistent asthma and moderate to severe allergic rhinitis who had been referred to Osh State Clinic in Osh city, Kyrgyz Republic, from March 2000 to February 2025. About 160 atopic patients with allergic rhinitis and asthma were included in the study; confirmed by history, physical examination, and SPT, irrespective of gender. In patients with allergic asthma, 23 (58.97%) patients showed complete symptom improvement, 11 (28.2%) patients showed complete improvement, and 5 (12.82%) patients showed no response to treatment. Compared to previous treatment in the allergic rhinitis group, the cytokine TGFβ was significantly increased (p < 0.001), while the levels of IFN-γ (p = 0.047) and FOXP3 (p = 0.013) were also insignificantly decreased after immunotherapy. This study examined the impact of standard subcutaneous immunotherapy on patients with allergic respiratory diseases.  The study also shows that immunotherapy stands as the most effective treatment for asthma and nasal allergies in patients who meet selection criteria, especially when medications do not work.

Keywords:

Asthma Allergies Immunotherapy Immune Response

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