Immune Response to Spray-Dried Porcine Plasma-Fed Diet: A Systematic Review and Meta-Analysis of Animal Model

Trends in Immunotherapy

Review Article

Immune Response to Spray-Dried Porcine Plasma-Fed Diet: A Systematic Review and Meta-Analysis of Animal Model

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https://doi.org/10.54963/ti.v9i4.1024
Ertegin, B., Jasim, A. M., Naji, H. A., Abbas, S. S., Abdulghani , I., & Dzhusupov, K. (2025). Immune Response to Spray-Dried Porcine Plasma-Fed Diet: A Systematic Review and Meta-Analysis of Animal Model. Trends in Immunotherapy, 9(4), 245–259. https://doi.org/10.54963/ti.v9i4.1024
Volume 9 Issue 4 (December 2025): In Progress
Copyright (c) 2025 Baigashkaev Ertegin, Abbas Mohemmed Jasim, Hasanain Amer Naji, Saif Salah Abbas, Intisar Abdulghani , Kenesh Dzhusupov
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Authors

  • Baigashkaev Ertegin

    Medical Faculty, Osh State University, Osh 723500, Kyrgyzstan
  • Abbas Mohemmed Jasim

    Department of Medical Laboratory Analysis, Al Mansour University College, Baghdad 10067, Iraq
  • Hasanain Amer Naji

    Department of Medical Laboratory Analysis, Al-Turath University, Baghdad 10013, Iraq
  • Saif Salah Abbas

    Department of Medical Laboratory Analysis, Al-Rafidain University College, Baghdad 10064, Iraq
  • Intisar Abdulghani

    Department of Medical Laboratory Analysis, Madenat Alelem University College, Baghdad 10006, Iraq
  • Kenesh Dzhusupov

    Public Health Department, International Higher School of Medicine, Bishkek 720054, Kyrgyzstan

Received: 14 February 2025; Revised: 3 March 2025; Accepted: 23 June 2025; Published: 10 December 2025

Spray-dried plasma (SDP), a byproduct of the meatpacking industry, is commonly used in swine diets to enhance growth and optimize feed utilization. Multiple studies have shown that animals' immune responses can be improved by giving them plasma proteins like SDP orally. This study aims to highlight the importance of non-invasive dietary interventions in stimulating immune responses and enhancing immunological characteristics. A comprehensive search was conducted using the indexing databases Scopus, PubMed/Medline, ISI Web of Science, Embase, Cochrane Central, and CINAHL and out of the 541 publications initially searched, only 13 fit the specified criteria. This meta-analysis incorporated seven trials, including a total of 210 animals. The SDP group had significantly lower IL-10 levels (SMD: −1.79, 95% CI: −2.43, −1.15, I2: 60%, p = 0.04) compared to the control group.  The SDP group showed statistically higher TNF-α (SMD: 2.32, 95% CI: 0.74, 3.89, I2: 92%, p = 0.004) than the control group.  Also, the SDP group showed statistically higher IgG (SMD: 0.59, 95% CI: 0.03, 1.15, I2: 54%, p = 0.04) than the control group. SDP alters cytokine secretion, promoting an anti-inflammatory immune profile. The positive impact of SDP in this model suggests that these supplements may help enhance immune responses.

Keywords:

Spray-Dried Porcine Plasma (SDPP) Intestinal Health Animal Model Meta-Analysis Cytokines

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