Trends in Immunotherapy

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Global Trends in Childhood Immunization Research: A Bibliometric Analysis of Publications from 1974 to 2025

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https://doi.org/10.54963/ti.v9i1.1010
Noya, J., Kusumawati, I., Lameky, V. Y., Batlajery, B. V., Syaripudin, A., & Sillehu, S. (2025). Global Trends in Childhood Immunization Research: A Bibliometric Analysis of Publications from 1974 to 2025. Trends in Immunotherapy, 9(1), 109–128. https://doi.org/10.54963/ti.v9i1.1010
Volume 9 Issue 1 (2025)
Copyright (c) 2025 Josephus Noya, Ira Kusumawati, Vernando Yanry Lameky, Belfrit Victor Batlajery, Ahmad Syaripudin, Sahrir Sillehu
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Authors

  • Josephus Noya
    Faculty of Social and Political Sciences, Department of Social Welfare, Universitas Kristen Indonesia Maluku, Ambon 97115, Indonesia
  • Ira Kusumawati STIKes RSPAD Gatot Soebroto, Jakarta 10410, Indonesia
  • Vernando Yanry Lameky Faculty of Health, Department of Nursing, Universitas Kristen Indonesia Maluku, Ambon 97115, Indonesia
  • Belfrit Victor Batlajery Department of Informatics, Faculty of Computer, Universitas Kristen Indonesia Maluku, Ambon 97115, Indonesia
  • Ahmad Syaripudin Institut Teknologi dan Kesehatan Mahardika, Cirebon 45135, Indonesia
  • Sahrir Sillehu STIKes Maluku Husada, Ambon 97566, Indonesia

Childhood immunization is a crucial public health intervention for preventing infectious diseases and reducing mortality. However, global immunization coverage faces challenges such as inequality in vaccine access, the rise of anti-vaccination movements, and the impact of the COVID-19 pandemic. This study aims to analyze global research trends in childhood immunization using a bibliometric approach. Data were collected from the Scopus database, and 629 research articles published between 1974 and 2025 were included in the analysis. The results showed a significant increase in publications over the decades, peaking in 2022. The United States, India, and China were the top contributors, while collaboration patterns revealed the United States and the United Kingdom as the main hubs of the global research network. The research focused on public health, vaccines, child health, and infectious diseases. The study also identified research gaps, including the need for more contextualized studies in developing countries and the integration of technological innovations. Future research should focus on interventions to reduce immunization pain, improve health systems, and address sociocultural barriers to immunization coverage. These findings provide valuable insights for policymakers, health practitioners, and researchers to strengthen childhood immunization programs and promote global child health.

Keywords:

Childhood Immunization; Bibliometric Analysis; Research Trends; Global Health

References

  1. Meleko, A.; Geremew, M.; Birhanu, F. Assessment of child immunization coverage and associated factors with full vaccination among children aged 12–23 months at Mizan Aman Town, Bench Maji Zone, Southwest Ethiopia. Int. J. Pediatr. 2017, 2017, 1–11. DOI: https://doi.org/10.1155/2017/7976587
  2. World Health Organization. Immunization Data [Internet]. World Health Organization: Geneva, Switzerland, 2024. Available from: https://immunizationdata.who.int/ (cited 4 February 2025).
  3. Kaur, G.; Sugerman, C.; Gacic-Dobo, M.; et al. Routine vaccination coverage - worldwide, 2022. MMWR Morb. Mortal. Wkly. Rep. 2023, 72, 1155–1161. DOI: https://doi.org/10.15585/mmwr.mm7243a1
  4. Faraji, N.; Zeinali, T.; Joukar, F.; et al. Mutational dynamics of SARS-CoV-2: Impact on future COVID-19 vaccine strategies. Heliyon 2024, 10, e30208. DOI: https://doi.org/10.1016/j.heliyon.2024.e30208
  5. Scharf, L.G.; Adeniyi, K.; Abbott, E.; et al. Current challenges and future possibilities for immunization information systems. Acad. Pediatr. 2021, 21, S57–S64. DOI: https://doi.org/10.1016/j.acap.2020.11.008
  6. Sahid, A.; Asemanjerdi, S.A.; Maleh, Y.; et al. A bibliometric analysis of the FinTech agility literature: Evolution and review. Int. J. Financ. Stud. 2023, 11, 123. DOI: https://doi.org/10.3390/ijfs11040123
  7. Jia, B.; Wei, R.; Yuan, C.; et al. A bibliometric analysis of vaccination against atherosclerosis. Hum. Vaccines Immunother. 2024, 20, 2365500. DOI: https://doi.org/10.1080/21645515.2024.2365500
  8. Damar, S.; Koksalmis, G.H. A bibliometric analysis of metaverse technologies in healthcare services. Serv. Bus. 2024, 18, 223–254. DOI: https://doi.org/10.1007/s11628-024-00553-3
  9. Soldan, K.; Stanley, M.; Harper, D.M. Decision letter: Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world. eLife 2021, 10, e67635. DOI: https://doi.org/10.7554/elife.67635.sa1
  10. Noble, H.; Smith, J. Issues of validity and reliability in qualitative research. Evid. Based Nurs. 2015, 18, 34–5. DOI: https://doi.org/10.1136/eb-2015-102054
  11. Lahariya, C. Vaccine epidemiology: A review. J. Family Med. Prim. Care 2016, 5, 7. DOI: https://doi.org/10.4103/2249-4863.184616
  12. Yin, Z. Conducted vaccine clinical trials and optimized immunization strategies. Zhonghua Yu Fang Yi Xue Za Zhi 2020, 54, 915–917. DOI: https://doi.org/10.3760/cma.j.cn112150-20200803-01084
  13. Htike, A.Z.; Aung, S.S.M.; Oo, W.M. Maternal knowledge on routine childhood immunization: A community-based cross-sectional study in rural area of Mon State, Myanmar. Asian J. Res. Infect. Dis. 2020, 3, 1–9. DOI: https://doi.org/10.9734/ajrid/2020/v3i230121
  14. Lehmann, B.A.; De Melker, H.E.; Timmermans, D.R.M.; et al. Informed decision-making in the context of childhood immunization. Patient Educ. Couns. 2017, 100, 2339–2345. DOI: https://doi.org/10.1016/j.pec.2017.06.015
  15. Choudhary, R.K.; Awasthi, S. Bibliometric visualisation tools. Libr. Prog. (Int.) 2018, 38, 319. DOI: https://doi.org/10.5958/2320-317x.2018.00034.x
  16. Kandeil, W.; Atanasov, P.; Avramioti, D.; et al. The burden of pertussis in older adults: What is the role of vaccination? A systematic literature review. Expert Rev. Vaccines 2019, 18, 439–455. DOI: https://doi.org/10.1080/14760584.2019.1588727
  17. Kabakama, S.; Amuasi, J.; Morhason-Bello, I.; et al. Commentary on COVID-19 vaccine hesitancy in Sub-Saharan Africa. Trop. Med. Infect. Dis. 2022, 7, 130. DOI: https://doi.org/10.3390/tropicalmed7070130
  18. Ram, Y.; Collins-Kreiner, N.; Gozansky, E.; et al. Is there a COVID-19 vaccination effect? A three-wave cross-sectional study. Curr. Issues Tour. 2021, 25, 379–86. DOI: https://doi.org/10.1080/13683500.2021.1960285
  19. Liang, L.-L.; McGuire, A.; Le, H.M.; et al. Human mobility increased with vaccine coverage and attenuated the protection of COVID-19 vaccination: A longitudinal study of 107 countries. J. Glob. Health 2023, 13, 06009. DOI: https://doi.org/10.7189/jogh.13.06009
  20. Chavda, V.P., Vora, L.K., Pandya, A.K.; et al. Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management. Drug Discov. Today 2021, 26, 2619–2636. DOI: https://doi.org/10.1016/j.drudis.2021.07.021
  21. Bai, Z.; Wan, D.; Lan, T.; et al. Nanoplatform-based intranasal vaccines: Current progress and clinical challenges. ACS Nano 2024, 18, 24650–24681. DOI: https://doi.org/10.1021/acsnano.3c10797
  22. Moher, D.; Altman, D.G., Tetzlaff, J.; et al. Reprint—Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Phys Ther. 2009, 89, 873–880. DOI: https://doi.org/10.1093/ptj/89.9.873
  23. Bukar, U.A.; Sayeed, M.S.; Razak, S.F.A.; et al. A method for analyzing text using VOSviewer. MethodsX 2023, 11, 102339. DOI: https://doi.org/10.1016/j.mex.2023.102339
  24. Tomaszewski, R. Visibility, impact, and applications of bibliometric software tools through citation analysis. Scientometrics 2023, 128, 4007–28. DOI: https://doi.org/10.1007/s11192-023-04725-2
  25. Warsy, A.; Warsy, I. Publish ethically or perish. J. Nat. Sci. Med. 2019, 2, 186. DOI: https://doi.org/10.4103/jnsm.jnsm_17_19
  26. Korsun, I.; Kryzhanovskyi, S.; Monchuk, M. The study of thermometers using Microsoft Excel. Phys. Educ. 2019, 54, 065004. DOI: https://doi.org/10.1088/1361-6552/ab350c
  27. Belt, R.V., Abdullah, S.; Dadari, I.; et al. Improving equity in urban immunization in low- and middle-income countries: A qualitative document review. Vaccines 2023, 11, 1200. DOI: https://doi.org/10.3390/vaccines11071200
  28. Zimba, O.; Gasparyan, A.Y. Social media platforms: A primer for researchers. Rheumatology 2021, 59, 68–72. DOI: https://doi.org/10.5114/reum.2021.102707
  29. Lee, G.; Michos, E.D., Choi, A.D. Social media as a means to disseminate and advocate cardiovascular research: Why, how, and best practices. Curr. Cardiol. Rev. 2021, 17, 122–128. DOI: https://doi.org/10.2174/1573403x15666191113151325
  30. Chinchilla-Rodríguez, Z.; Larivière, V.; Sugimoto, C.R. Follow the leader: The relationship between leadership and scholarly impact in international collaborations. PLoS ONE 2019, 14, e0218309. DOI: https://doi.org/10.1371/journal.pone.0218309
  31. Woldemichael, A.; Olyaeemanesh, A.; Takian, A.; et al. Availability and inequality in accessibility of health centre-based primary healthcare in Ethiopia. PLoS ONE 2019, 14, e0213896. DOI: https://doi.org/10.1371/journal.pone.0213896
  32. Erdiwansyah, E.; Mamat, R.; Sani, M.S.M.; et al. Renewable energy in Southeast Asia: Policies and recommendations. Sci. Total Environ. 2019, 670, 1095–1102. DOI: https://doi.org/10.1016/j.scitotenv.2019.03.273
  33. Overland, I.; Fossum Sagbakken, H.; Isataeva, A.; et al. Funding flows for climate change research on Africa: Where do they come from and where do they go? Clim. Dev. 2021, 14, 705–24. DOI: https://doi.org/10.1080/17565529.2021.1976609
  34. Lei, L.; Ozturk, I.; Murshed, M.; et al. Environmental innovations, energy innovations, governance, and environmental sustainability: Evidence from South and Southeast Asian countries. Resour. Policy 2023, 82, 103556. DOI: https://doi.org/10.1016/j.resourpol.2023.103556
  35. Butler, J.; Foot, C.; Bomb, M.; et al. The International Cancer Benchmarking Partnership: An international collaboration to inform cancer policy in Australia, Canada, Denmark, Norway, Sweden, and the United Kingdom. Health Policy 2013, 112, 148–155. DOI: https://doi.org/10.1016/j.healthpol.2013.03.021
  36. Bharti, M.S. The strategic partnership between India and the United States of America and how China’s influence challenges the India-US alliance in the Indo-Pacific region. Reg. Form. Dev. Stud. 2023, 36, 2507. DOI: https://doi.org/10.15181/rfds.v36i1.2507
  37. Holipah, H.; Kuroda, Y.; Maharani, A. Determinants of immunization status among 12- to 23-month-old children in Indonesia (2008–2013): A multilevel analysis. BMC Public Health 2018, 18, 288. DOI: https://doi.org/10.1186/s12889-018-5193-3
  38. Djalante, R. Review article: A systematic literature review of research trends and authorships on natural hazards, disasters, risk reduction, and climate change in Indonesia. Nat. Hazards Earth Syst. Sci. 2018, 18, 1785–1810. DOI: https://doi.org/10.5194/nhess-18-1785-2018
  39. Murthy, N.; Fiebelkorn, A.P., Ng, T.; et al. Progress in childhood vaccination data in immunization information systems - United States, 2013-2016. MMWR Morb. Mortal. Wkly. Rep. 2017, 66, 1178–1181. DOI: https://doi.org/10.15585/mmwr.mm6643a4
  40. Syiroj, A.T.R.; Pardosi, J.F.; Heywood, A.E. Exploring parents' reasons for incomplete childhood immunization in Indonesia. Vaccine 2019, 37, 6486–6493. DOI: https://doi.org/10.1016/j.vaccine.2019.08.081
  41. Hardhantyo, M.; Chuang, Y.-C. Urban-rural differences in factors associated with incomplete basic immunization among children in Indonesia: A nationwide multilevel study. Pediatr. Neonatol. 2020, 62, 80–89. DOI: https://doi.org/10.1016/j.pedneo.2020.09.004
  42. Restrepo-Méndez, M.C.; Johnson, H.L.; Barros, A.J.; et al. Inequalities in full immunization coverage: Trends in low- and middle-income countries. Bull. World Health Organ. 2016, 94, 794B–805B. DOI: https://doi.org/10.2471/blt.15.162172
  43. Rahman, A.; Usman, A.; Nursasmita, R. Audio visual and its impact on pain during immunization. Int. Health Sci. J. 2024, 2, 33–40. DOI: https://doi.org/10.61777/ihsj.v2i1.61
  44. Öztürk Danişman, G. Technological innovations and firm internationalisation. Sosyoekonomi 2022, 30, 71–85. DOI: https://doi.org/10.17233/sosyoekonomi.2022.02.05.
  45. Anderson, J.G.; Taylor, A.G. Effects of Healing Touch in clinical practice. J. Holist. Nurs. 2011, 29, 221–228. DOI: https://doi.org/10.1177/0898010110393353
  46. Hall, L.F. Implementation of Healing Touch in the acute care setting. Pain Manag. Nurs. 2023, 24, 236. DOI: https://doi.org/10.1016/j.pmn.2023.02.014
  47. Nayak, S.; Naik, D. Community participation for health systems strengthening - A decade of experience in sustaining community interventions in NHM, Odisha. GIS Bus. 2020, 15, 149–57. DOI: https://doi.org/10.26643/gis.v15i1.17961.
  48. Siramaneerat, S.; Agushybana, A. Inequalities in immunization coverage in Indonesia: A multilevel analysis. Rural Remote Health 2021, 21, 6348. DOI: https://doi.org/10.22605/rrh6348.
  49. Lopez, M.A. Technology-Based Interventions to Address Pediatric Health Disparities. Springer: Cham, Switzerland. 2018; pp. 31–37. DOI: https://doi.org/ https://doi.org/10.1007/978-3-030-03210-4_4
  50. Şen Celasi̇n, N.; Dur, Ş.; Karaarslan, D.; et al. Knowledge, attitude and clinical decision-making abilities of pediatric nurses regarding pain management. Clin. Exp. Health Sci. 2020, 10, 416–422. DOI: https://doi.org/10.33808/marusbed.669905
  51. Nigussie, J.; Mareg, M.; Molla, A.; et al. Tetanus toxoid immunization coverage and associated factors in Ethiopia: A systematic review and meta-analysis. Res. Sq. Platform. LLC 2020, 1–18. DOI: https://doi.org/10.21203/rs.3.rs-82002/v1
  52. Adongo, E.A.; Ganle, J.K. Predictors of neonatal mortality in Ghana: Evidence from 2017 Ghana maternal health survey. BMC Pregnancy Childbirth 2023, 23, 556. DOI: https://doi.org/10.1186/s12884-023-05877-y
  53. Heggie, J. The Journey through Perspective Transformation: Learning Nursing Theory [Internet]. University of San Diego Copley Library: San Diego, CA, USA, 2021. DOI: https://doi.org/10.22371/07.1998.004
  54. Clarke, P.N. Nursing theory informs dressage. Nurs. Sci. Q. 2019, 33, 35–37. DOI: https://doi.org/10.1177/0894318419881799