Inflammatory responses play a crucial role in the pathogenesis of depression. The Systemic Immune Inflammatory Index (SII) is a novel composite inflammatory marker that integrates the counts of neutrophils, lymphocytes, and platelets. However, the relationship between it and depressive symptoms is still not very clear at present. This exploratory study conducted in this article aims to investig...

The challenge in the management of pubic vitiligo lies in the sensitive nature of the area and the relatively lower efficacy of the existing management approaches. This study aimed to evaluate the efficacy and safety of autologous hair follicle transplantation combined with narrow-band ultraviolet B (NB-UVB) phototherapy for stable pubic vitiligo. Sixty-eight patients were randomly assigned (1:...

Muscular dystrophies include myotonic dystrophy (MD). Although there is no cure for this disorder, many treatments can manage symptoms and reduce disease development. Standard pharmacological treatments and rehabilitation methods have largely failed, prompting researchers to investigate stem cell and gene therapy options. This review will discuss gene therapy and stem cell therapy as adjuvant t...

Ulcerative colitis (UC) is an immune-mediated inflammatory disease characterized by excessive pro-inflammatory cytokine activity and impaired immune regulation. Fecal microbiota transplantation (FMT) has emerged as a microbiome-based immunotherapeutic approach, yet its effects on systemic immune responses in UC remain incompletely understood. This study examined the immunomodulatory impact of F...

In oncology, the development of intelligent, biocompatible nanocarriers is pivotal for advancing targeted immunotherapy. This study presents a protein-binding immunotherapy model that leverages targeted immune proteins, such as interleukins, interferons, and checkpoint inhibitors, integrated with a drug delivery system (DDS). The proposed Zn²⁺-glutamic acid (Glu) nanocarrier, optimized via the ...

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by the production of antinuclear antibodies (ANA). While murine models are widely used for lupus research, their translational value is limited by physiological differences. Macaca fascicularis, a non-human primate, offers a closer model due to its genetic and immunological similarities to humans. Pristane...

Diarrhea remains a major cause of morbidity in children under five, and although current management is mainly supportive, Vitamin D₃ supplementation has emerged as a potential immunomodulatory approach whose clinical efficacy requires further clarification. This study aimed to evaluate the effect of Vitamin D₃ supplementation on clinical outcomes, specifically diarrhea frequency, duration, and ...

Long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression involved in tumor initiation, progression, and metastasis. Among them, HOTAIR (HOX Transcript Antisense Intergenic RNA) and MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) have been implicated in several cancers, including breast cancer. However, their stage-specific expression patterns and prognost...

Systematic reviews and meta-analyses investigated VDR gene polymorphism correlations with T1D and T2D outcomes. We reviewed and meta-analyzed all VDR gene polymorphism research, including clinical outcome case-control studies. We conducted a comprehensive review using systematic data analysis to evaluate the association between VDR gene polymorphism and the risk of diabetes. According to the pr...

Type 2 diabetes mellitus (T2DM) is a pervasive chronic metabolic disorder characterized by insulin resistance and hyperglycemia. While conventional treatments exist, there is groqing interest in complementary and alternative therapies, particularyl for patients with poorly controlled disease. . Among these, bloodletting therapy of Traditional Mongolian medicine (TMM) has historical roots, yet i...

Allergic diseases are increasingly recognized as a worldwide public health problem, affecting countries at all levels of economic growth. In recent years, it has been proposed that allergic diseases result from excessive type 2 inflammation, which is driven by cooperative interactions between the innate and acquired immune systems. In this model, allergens, pathogen-associated molecular pattern...

Hypothyroidism, characterized by insufficient thyroid hormone production, is frequently associated with iodine deficiency. Selenium is essential for thyroid hormone metabolism and immune regulation. This study examined the effects of iodinated casein and selenomethionine supplementation on thyroid function and immune-inflammatory markers in a rat model of hypothyroidism. Thirty-six male Wistar ...

Wound healing is a critical global clinical issue, particularly in surgical and emergency care settings, where infections lead to significant morbidity, extended hospitalization, and increased healthcare costs. This study investigated the impact of altitude deadaptation on immune responses during wound healing in rabbits. Animals with aseptic and purulent wounds were divided into three groups: ...

To examine the immunopathological mechanisms underlying heart failure with preserved ejection fraction (HFpEF) in elderly patients and evaluate exercise training as an immunomodulatory intervention for managing disease complications. A narrative literature review was conducted using PubMed, Embase, and Cochrane Library databases (2010–2023), focusing on immune dysfunction, aging, and exercise i...

Periodontitis is a common and persistent inflammatory disease resulting from a sophisticated relationship between oral bacteria and the body's immune system. Toll-like receptors (TLRs) act as crucial sensors within the immune response, playing a fundamental role in the disease's initiation and progression. This review examines periodontitis, highlighting the limited understanding of TLR activat...

Dengue remains a leading cause of child mortality in Indonesia. Identifying reliable biomarkers to predict disease severity is essential for early intervention. Macrophage Migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine involved in the pathogenesis of dengue. This study aimed to assess the relationship between MIF levels and dengue severity in children, and to compare  the pred...