Trends in Immunotherapy

Review

A potential role of nanophytocompounds in diabetic foot ulcers

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https://doi.org/10.24294/ti.v8.i2.4186
Thapa, K., Kanojia, N., & Verma, N. (2024). A potential role of nanophytocompounds in diabetic foot ulcers. Trends in Immunotherapy, 8(2). https://doi.org/10.24294/ti.v8.i2.4186
Volume 8 Issue 2 (2024)
Copyright (c) 2024 Komal Thapa, Neha Kanojia, Nitin Verma
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Authors

  • Komal Thapa
  • Neha Kanojia
    Chitkara University School of Pharmacy, Chitkara University, Baddi 174103, Himachal Pradesh, India
  • Nitin Verma

Diabetes mellitus (DM) is characterized by hyperglycemia, which is a common endocrine disease. DM and its complications may lead to diabetic foot ulcers (DFU). DFU is associated with reduced wound healing because of altered cellular and cytokine responses, inadequate vascularization, infection, and neuropathy. One novel and promising approach to treating diabetic wound healing is the administration of compounds based on nanotherapeutics, such as nanoparticles and nanoscaffolds. Plant extracts can be administered more successfully by using nanoscale delivery methods. Plant extracts and their related phytocompounds can be nanostructured to enhance their bioavailability, regulate their release via extended delivery techniques to the wound site, and increase their penetration to the deeper layers of the skin. All these benefits are critical for the healing process. This brief overview covers the most recent methods to develop phytomedicine nanotherapeutics for the treatment of diabetic wounds.

Keywords:

diabetic mellitus drug delivery system foot ulcer nanoformulation phytocompounds wound healing

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