Trends in Immunotherapy

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The expression of autophagy-associated protein LC3, metastasis, and chemotherapy response in colorectal cancer patients receiving uracil-based chemotherapy: An observational study

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https://doi.org/10.24294/ti.v8.i1.3225
Riskie Aditya Putra, M., Rudiman, R., Lukman, K., Am Am Setya Sulthana, B., Purnama, A., Ruchimat, T., Wijaya, A., Nugraha, P., & Rahmawan, A. (2024). The expression of autophagy-associated protein LC3, metastasis, and chemotherapy response in colorectal cancer patients receiving uracil-based chemotherapy: An observational study. Trends in Immunotherapy, 8(1). https://doi.org/10.24294/ti.v8.i1.3225
Volume 8 Issue 1 (2024)
Copyright (c) 2024 Mochammad Riskie Aditya Putra, Reno Rudiman, Kiki Lukman, Bambang Am Am Setya Sulthana, Andriana Purnama, Tommy Ruchimat, Alma Wijaya, Prapanca Nugraha, Andhika Rahmawan
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Trends in Immunotherapy (TI)  publishes accepted manuscripts under Creative Commons Attribution 4.0 International (CC BY 4.0). Authors who submit their papers for publication by TI agree to have the CC BY 4.0 license applied to their work, and that anyone is allowed to reuse the article or part of it free of charge for any purpose, including commercial use. As long as the author and original source are properly cited, anyone may copy, redistribute, reuse, and transform the content.

Authors

  • Mochammad Riskie Aditya Putra
  • Reno Rudiman
  • Kiki Lukman
    Division of Digestive Surgery, Department of Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung 40161, Indonesia
  • Bambang Am Am Setya Sulthana
  • Andriana Purnama
  • Tommy Ruchimat
  • Alma Wijaya
  • Prapanca Nugraha
  • Andhika Rahmawan

Background: LC3 serves as a marker for assessing autophagy activity in cancer cells, which is a potential focus for therapeutic interventions. It holds the potential to serve as a predictive indicator of resistance to chemotherapy in colorectal cancer. Thus, this study is aimed at finding the association between LC3 expression, metastasis, and chemotherapy response in colorectal patients. Methods: This study was an observational study evaluating the stage and chemotherapy response of a colorectal cancer patient in a tertiary hospital in West Java, Indonesia. The research participants included in this study were 83 subjects. The examination of LC3 was performed with immunohistochemistry. The response evaluation criteria in solid tumors (RECIST) were used for the evaluation of the chemotherapy response. Results: A positive LC3 expression was shown in 58 (69.9%) patients. In positive LC3 expression, 20 subjects (27.4%) showed progressive response, 16 subjects (21.9%) showed stable response, 12 subjects (16.4%) showed partial response, and 1 subject (1.4%) showed complete response. Meanwhile, in negative LC3 expression, 12 subjects (16.4%) showed progressive response, 8 subjects (11%) showed stable response, 3 subjects (4.1%) showed partial response, and 1 subject (1.4%) showed complete response. The LC3 expression showed no significant relationship with age, sex, subtype, grade, tumor location, stage, or chemotherapy response (p > 0.05). Conclusion: The expression of LC3 showed no significant relationship with metastasis or chemotherapy response.

Keywords:

autophagy chemotherapy colorectal cancer LC3 metastases

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