Trends in Immunotherapy

Article

Synthetic naphthoquinone derivatives suppressed nitric oxide and prostaglandin E2 production

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https://doi.org/10.24294/ti.v7.i2.2417
Ocampo, Y., Castro, J., Piermattey, J., Gaitan, R., & Franco, L. (2023). Synthetic naphthoquinone derivatives suppressed nitric oxide and prostaglandin E2 production. Trends in Immunotherapy, 7(2). https://doi.org/10.24294/ti.v7.i2.2417
Volume 7 Issue 2 (2023)

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Authors

  • Yanet Ocampo Biological Evaluation of Promising Substances Group, Facultad de Ciencias Farmacéuticas, Universidad de Cartagena, 130014 Cartagena, Colombia
  • Jenny Castro Biological Evaluation of Promising Substances Group, Facultad de Ciencias Farmacéuticas, Universidad de Cartagena, 130014 Cartagena, Colombia; Facultad de Química y Farmacia, Universidad del Atlántico, 081001 Puerto Colombia, Colombia
  • Jhoan Piermattey Natural Products Group, Facultad de Ciencias Farmacéuticas, Universidad de Cartagena, 130014 Cartagena, Colombia
  • Ricardo Gaitan Natural Products Group, Facultad de Ciencias Farmacéuticas, Universidad de Cartagena, 130014 Cartagena, Colombia
  • Luis Franco
    Biological Evaluation of Promising Substances Group, Facultad de Ciencias Farmacéuticas, Universidad de Cartagena, 130014 Cartagena, Colombia

Objectives: To synthesize and evaluate the anti-inflammatory potential of fifteen naphthoquinones (NQs), determining their ability to inhibitory nitric oxide (NO•) and prostaglandin E2 (PGE2) production. Methods: NQs were screened for their inhibitory effect on NO• and PGE production using LPS-activated RAW 264.7 macrophages. Results: Three linear furanonaphthoquinones (4-6) were identified as potent inhibitors of NO• and PGE2 production, with IC50 values ranging from 0.45 to 2.86 μM (NO•) and 0.38 to 1.65 (PGE2), highlighting the potent activity showed by compound 5 with IC50 values lower than one and high selectivity indices. Conclusions: Synthesized furanonaphthoquinones constitute leading compounds for the design of new anti-inflammatory agents and provide a valuable tool for designing new NQs that might be useful to treat inflammation. The evaluation of compounds 4-6 using in vivo models is warranted.

Keywords:

anti-inflammatory activity synthesis substituent effect quinones RAW 264.7 macrophages

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