Trends in Immunotherapy

Case Report

Summary of COVID-19 vaccine-related erythema multiforme at Kindai University Hospital, Japan

Downloads

https://doi.org/10.24294/ti.v6.i2.1653
Watanabe, K., Nakashima, C., Matsuo, A., Kato, M., Yanagihara, S., Oiso, N., & Otsuka, A. (2022). Summary of COVID-19 vaccine-related erythema multiforme at Kindai University Hospital, Japan. Trends in Immunotherapy, 6(2). https://doi.org/10.24294/ti.v6.i2.1653
Volume 6 Issue 2 (2022)

Copyright

The authors shall retain the copyright of their work but allow the Publisher to publish, copy, distribute, and convey the work.

License

Trends in Immunotherapy (TI)  publishes accepted manuscripts under Creative Commons Attribution 4.0 International (CC BY 4.0). Authors who submit their papers for publication by TI agree to have the CC BY 4.0 license applied to their work, and that anyone is allowed to reuse the article or part of it free of charge for any purpose, including commercial use. As long as the author and original source are properly cited, anyone may copy, redistribute, reuse, and transform the content.

Authors

  • Keiko Watanabe Department of Dermatology, Faculty of Medicine, Kindai University Hospital
  • Chisa Nakashima
    Department of Dermatology, Faculty of Medicine, Kindai University Hospital, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan
  • Ayako Matsuo
  • Maiko Kato
  • Shigeto Yanagihara
  • Naoki Oiso
  • Atsushi Otsuka

The recently extended use of mRNA vaccines due to the COVID-19 pandemic has allowed the description of multiple cutaneous adverse events including local injection site reactions, urticaria, and morbilliform eruptions. COVID-19 vaccine-related cutaneous reaction patterns can be divided into type Ⅰ hypersensitivity reactions, type Ⅳ hypersensitivity reactions, autoimmune-related, and functional angiopathies based on pathogenesis. Erythema multiforme (EM), a type IV hypersensitivity reaction, has also been reported from several centers. We experienced the remarkable improvement of COVID-19 vaccine-related EM with systemic administration of prednisolone and summarized six cases experienced in our department.

Keywords:

COVID-19 Erythema Multiforme Vaccination

References

  1. Gambichler T, Boms S, Susok L, et al. Cutaneous findings following COVID-19 vaccination: Review of world literature and own experience. Journal of the European Academy of Dermatology and Venereology 2022; 36(2): 172–180. doi: 10.1111/jdv.17744.
  2. McMahon DE, Amerson E, Rosenbach M, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Journal of the American Academy of Dermatology 2021; 85(1): 46–55. doi: 10.1016/j.jaad.2021.03.092.
  3. Grieco T, Maddalena P, Sernicola A, et al. Cutaneous adverse reactions after COVID-19 vaccines in a cohort of 2740 Italian subjects: An observational study. Dermatologic Therapy 2021; 34(6): e15153. doi: 10.1111/dth.15153.