Trends in Immunotherapy

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Prevalence, Demographics, and Clinical Characteristics of Nephroptosis in Kyrgyzstan: A Three-Year Retrospective Study

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https://doi.org/10.54963/ti.v9i2.1113
Chyngyz Imanaliev, Guliya Sadybakasova, Asel Imankulova, Nurbek Monolov, Akman Kadyrbekov, & Yethindra Vityala. (2025). Prevalence, Demographics, and Clinical Characteristics of Nephroptosis in Kyrgyzstan: A Three-Year Retrospective Study. Trends in Immunotherapy, 9(2), 73–83. https://doi.org/10.54963/ti.v9i2.1113
Volume 9 Issue 2 ( 2025)
Copyright (c) 2025 Chyngyz Imanaliev, Guliya Sadybakasova, Asel Imankulova, Nurbek Monolov, Akman Kadyrbekov, Yethindra Vityala
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Authors

  • Chyngyz Imanaliev

    Department of Urology, DOC University Clinic, Salymbekov University, Bishkek 760000, Kyrgyzstan
  • Guliya Sadybakasova

    Department of Microbiology, Salymbekov University, Bishkek 720054, Kyrgyzstan
  • Asel Imankulova

    Disaster Medicine Department, Peoples’ Friendship University of Russia Named after Patrice Lumumba, Moscow 117198, Russia
  • Nurbek Monolov

    Department of Clinical and Morphological Disciplines, Salymbekov University, Bishkek 720054, Kyrgyzstan
  • Akman Kadyrbekov

    Department of Urology, Salymbekov University, Bishkek 720054, Kyrgyzstan
  • Yethindra Vityala

    Department of Pathology, International Higher School of Medicine, Bishkek 720054, Kyrgyzstan

Received: 21 March 2025; Revised: 12 May 2025; Accepted: 23 May 2025; Published: 5 June 2025

Nephroptosis (NP), which is marked by excessive movement of the kidneys, has attracted renewed attention due to advancements in imaging technology. This retrospective study aimed to determine the prevalence, demographics, and clinical characteristics of NP in Kyrgyzstan using ultrasound Doppler examinations. Data from 13,235 patients at the Salymbekov University Clinic Network were analyzed over a period of three years. NP was detected in 378 (2.9%), with a higher prevalence in females (79.4%) than in males (20.6%). The most affected age group  was 20–40 years (58.5%), and right-sided NP predominated (75.1%). The number of NP cases increased annually, suggesting improved detection or changing trends. Comorbidities were found present in 57.9% of patients, with lupus nephritis (LN) being the most common (16.4%). Multivariate logistic regression analysis indicated that sex was not a significant predictor of LN in patients with NP. Immunosuppressive therapy with prednisone and cyclophosphamide improved kidney function in patients with NP and LN, although persistent symptoms required additional management or surgery in some cases. This highlights the importance of early detection and multidisciplinary management of NP. This study provides insights into the epidemiological patterns and clinical implications of NP in Kyrgyzstan, emphasizing the need for targeted screening, standardized diagnostic criteria, and preventive strategies for high-risk groups.

Keywords:

Nephroptosis; Ultrasound Doppler; Epidemiology; Kyrgyzstan; Prevalence; Lupus Nephritis

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