Wildfires pose a growing global danger for ecosystems and human activities. The degraded ecosystem functions of burnt sites, include, among others, shifts in hydrological processes, land cover, vegetation, and soil erosion, that make them more vulnerable to flood and extreme sediment transport risks. Several post-fire erosion and flood protection treatments (PFPs) have been developed to avoid and mitigate such consequences and risks. The Mediterranean region faces severe climate change challenges that are projected to escalate the wildfire and post-fire flood risks. However, there is limited research on the dynamics of post-fire flood risks and their mitigation through the design of the appropriate PFPs. This paper aims to cover this gap by simulating a real post-fire flash-flood event in Central Greece, and design the PFPs for this case study, considering their suitability and costs. An integrated framework was used to represent the flood under the baseline scenario: the storm conditions that caused the flood were simulated using the atmospheric model WRF-ARW; the burn extent, severity, and the flood extent were retrieved through remote sensing analyses; and a HEC-RAS hydraulic-hydrodynamic model was developed to simulate the flood event, applying the rain-on-grid technique. Several PFPs were assessed, and certain channel- and barrier-based PFPs were selected as the most suitable for the study area. The recommended PFPs were spatially represented within a geographic information system (GIS). Moreover, we present a detailed analysis of their expected costs. This study provides an interdisciplinary and transferable framework for understanding and enhancing the flood resilience of burnt sites.