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Evaluation of mean platelet volume and neutrophil to lymphocyte ratio as a diagnostic indicator in patients with recurrent aphthous stomatitis

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https://doi.org/10.2399/jmu.2016002008
Şereflican, M., Şereflican, B., Tuman, B., Göksügür, N., Kesgin, S., & Yurttaş, V. (2016). Evaluation of mean platelet volume and neutrophil to lymphocyte ratio as a diagnostic indicator in patients with recurrent aphthous stomatitis. ENT Updates, 6(2). https://doi.org/10.2399/jmu.2016002008
Volume 6 Issue 2 (2016)
Copyright (c) 2016 Murat Şereflican, Betül Şereflican, Bengü Tuman, Nadir Göksügür, Selcan Kesgin, Veysel Yurttaş
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Murat Şereflican
    Department of Otolaryngology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey
  • Betül Şereflican Department of Dermatology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey
  • Bengü Tuman Department of Dermatology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey
  • Nadir Göksügür Department of Dermatology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey
  • Selcan Kesgin Department of Otolaryngology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey
  • Veysel Yurttaş Department of Otolaryngology, Faculty of Medicine, Abant İzzet Baysal University, Bolu, Turkey

Objective: Recurrent aphthous stomatitis (RAS) is a chronic inflammatory disease of oral mucosa characterized by recurrent painful ulcers. Despite it is a condition seen frequently, its etiology and pathogenesis are not known fully. Its etiology is reportedly idiopathic or multifactorial. Mean platelet volume (MPV) indicates thrombocytic activation, while neutrophil/lymphocyte rate (NLR) is an indicator of chronic inflammation, and both of them can be measured during routine whole blood analysis. The aim of this study is to investigate MPV and NLR values in patients with RAS and the control group.

Methods: A total of 39 patients with RAS and 34 control subjects were included in the study.

Results: When the patient and the control groups were compared, MPV, ESR, CRP and vitamin B12 values were significantly higher in the patient group while NLR, WBC, hemoglobin, neutrophil and lymphocyte values were not significantly different between both groups.

Conclusion: It was shown that MPV can be used as a diagnostic indicator in patients with RAS.

Keywords:

Recurrent aphthous stomatitis mean platelet volume neutrophil/lymphocyte ratio