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Cytokine gene polymorphisms and expression in Turkish pediatric cochlear implant patients

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https://doi.org/10.2399/jmu.2016001002
Baysal, E., Oğuzkan Balcı, S., Çelenk, F., Kahraman, M., Deniz, M., Tunç, O., Durucu, C., Mumbuç, S., Kanlıkama, M., & Pehlivan, S. (2016). Cytokine gene polymorphisms and expression in Turkish pediatric cochlear implant patients. ENT Updates, 6(1). https://doi.org/10.2399/jmu.2016001002
Volume 6 Issue 1 (2016)
Copyright (c) 2016 Elif Baysal, Sibel Oğuzkan Balcı, Fatih Çelenk, Merve Kahraman, Murat Deniz, Orhan Tunç, Cengiz Durucu, Semih Mumbuç, Muzaffer Kanlıkama, Sacide Pehlivan
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Elif Baysal Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Sibel Oğuzkan Balcı Department of Medical Biology and Genetics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Fatih Çelenk Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Merve Kahraman Department of Medical Biology and Genetics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Murat Deniz Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Orhan Tunç Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Cengiz Durucu Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Semih Mumbuç Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Muzaffer Kanlıkama Department of Otolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
  • Sacide Pehlivan
    Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

Objective: We assessed the association between the polymorphisms and expressions of three cytokine genes and clinical parameters in children who underwent cochlear implantation due to profound congenital sensorineural hearing loss.

Methods: We analyzed the IL-6/-174, IFN-γ/+874 and TNF-α/- 308 genes in 64 cases with congenital sensorineural hearing loss and in 70 healthy controls. Cytokine genotyping/expression was performed using the PCR-SSP method.

Results: No significant differences were detected between the patient group and the healthy controls with respect to the distributions and numbers of genotypes and alleles of TNF-α or IL-6. However, the TT genotype, associated with high expression of IFN-γ, and the T allele frequency were significantly more frequent in the patient group versus the controls (p=0.016 and 0.023, respectively).

Conclusion: Our results suggest that high expression of the IFN-γ gene may be associated with susceptibility to the disease. Consequently, IFN-γ may be a useful marker of the etiopathogenesis of congenital sensorineural hearing loss.

Keywords:

Konjenital iflitme kayb› sitokin geni varyasyon