ENT Updates

Clinical Research

Predictors of neck metastasis in early stage oral cavity cancer

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https://doi.org/10.2399/jmu.2015002007
Ertuğrul, S., Ertuğrul, G., İmre, A., Pınar, E., Çallı, Çağlar, Orgen Çallı, A., & Öncel, S. (2015). Predictors of neck metastasis in early stage oral cavity cancer. ENT Updates, 5(2). https://doi.org/10.2399/jmu.2015002007
Volume 5 Issue 2 (2015)
Copyright (c) 2015 Süha Ertuğrul, Gökşen Ertuğrul, Abdulkadir İmre, Ercan Pınar, Çağlar Çallı, Aylin Orgen Çallı, Semih Öncel
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Süha Ertuğrul
    Department of Otorhinolaryngology, Karabük University Karabük Training and Research Hospital, Karabük, Turkey
  • Gökşen Ertuğrul Department of Dermatology and Veneral Disease, Karabük University Karabük Training and Research Hospital, Karabük, Turkey
  • Abdulkadir İmre Department of Otorhinolaryngology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, İzmir, Turkey
  • Ercan Pınar Department of Otorhinolaryngology, Atatürk Training and Research Hospital, Izmir Katip Çelebi University, Izmir, Turkey
  • Çağlar Çallı Department of Otorhinolaryngology, Ekol Otorhinolaryngology Hospital, İzmir, Turkey
  • Aylin Orgen Çallı Department of Pathology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, Turkey
  • Semih Öncel Vocational Collage, Dokuz Eylül University, İzmir, Turkey

Objective: To identify the effects of clinical and histopathological parameters on neck metastasis in early-stage oral cavity cancers.

Methods: The medical records of 92 patients who underwent primary surgical resection and concurrent neck dissection due to early-stage oral cavity squamous cell cancer at ‹zmir Atatürk Training and Research Hospital between June 2001 and June 2010 were retrospectively reviewed. The associations of clinical and histological parameters with neck metastasis were assessed. Based on the histological data, the histological sections of the operative tissue were obtained via the measurement of tumor width and tumor depth. Using an optical micrometer, the maximum width at the horizontal plane and the maximum depth at the vertical plane were measured and the maximum depth was recorded as tumor thickness.

Results: The association between neck metastasis and tumor localization, T stage, degree of differentiation, tumor thickness, perineural invasion, vascular invasion and perilymphatic invasion in early-stage oral cavity cancers was found statistically significant (p<0.05). The value of critical tumor thickness for the neck metastasis was found to be 5.6 mm.

Conclusion: On the basis of our results, a tumor thickness of 5.6 mm is the critical value for the development of neck metastasis in oral cavity cancers. The neck metastasis risk showed a significant increase in cases where the tumor thickness exceeded this threshold value. In oral cavity cancers with a high risk of occult metastasis, the tumor thickness may be identified pre-operatively or intra-operatively and, a decision can be taken to perform neck dissection when they exceed critical values.

Keywords:

Neck metastasis oral cavity cancer tumor thickness