ENT Updates

Clinical Research

Effects of a proton pump inhibitor on laryngeal irritation in patients with laryngopharyngeal reflux

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https://doi.org/10.2399/jmu.2015002002
Külekçi, M., Budun, R., Özgür Avinçsal, M., Dizdar, D., Ulusoy, S., Necati Develioğlu, Ömer, & Topak, M. (2015). Effects of a proton pump inhibitor on laryngeal irritation in patients with laryngopharyngeal reflux. ENT Updates, 5(2). https://doi.org/10.2399/jmu.2015002002
Volume 5 Issue 2 (2015)
Copyright (c) 2015 Mehmet Külekçi, Rıdvan Budun, Mehmet Özgür Avinçsal, Denizhan Dizdar, Seçkin Ulusoy, Ömer Necati Develioğlu, Murat Topak
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Mehmet Külekçi Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
  • Rıdvan Budun Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
  • Mehmet Özgür Avinçsal
    Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
  • Denizhan Dizdar Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
  • Seçkin Ulusoy Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
  • Ömer Necati Develioğlu Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
  • Murat Topak Department of Otorhinolarynology, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey

Objective: To evaluate laryngeal irritation before and after treatment using the reflux symptom index (RSI) in patients diagnosed with laryngopharyngeal reflux (LFR).

Methods: A total of 30 patients who were diagnosed with LFR after 24 hours of dual-probe pH monitoring were included in the study. RSI was applied to the patients before and after treatment. In evaluating the patients’ symptoms, throat clearing need and post-nasal drainage, which are frequently observed in LFR, were evaluated post-treatment. The patients were followed for 3 months during proton pump inhibitor treatment. Data regarding the patients’ LFR symptoms were obtained after 3 months, and the responses to treatment based on reflux symptom scale scores, post-nasal drainage, and throat clearing need were evaluated and compared with those pre-treatment.

Results: The decrease in the RSI for postnasal drainage value was statistically significant after treatment. The decrease in the throat clearing RSI value was statistically significant after treatment.

Conclusion: In patients with persistent postnasal drainage and throat clearing need complaints, if no infection source is identified, the patients should be evaluated by 24-hour pH monitorization in terms of LFR, irrespective of the presence or absence of laryngoscopic findings. 

Keywords:

Laryngopharyngeal reflux pH monitoring