Chimeric antigen receptor (CAR) T-cell therapies and bispecific T-cell engagers have produced durable remissions in haematological malignancies that were previously considered refractory, and the bispecific class has now extended this approach to a solid tumour, extensive-stage small-cell lung cancer, through the delta-like ligand 3 engager tarlatamab. The shared mechanism of intense, sustained...

Chronic inflammation and immune dysregulation are key contributors to the development and progression of metabolic diseases, including type 2 diabetes mellitus (T2DM). Natural phytochemicals capable of modulating inflammatory signaling pathways have attracted increasing interest as potential multi-target therapeutic agents. This study investigated the predicted immunomodulatory and antidiabetic...

Global organ shortages have intensified interest in donation after circulatory death (DCD). However, DCD kidneys are affected by warm ischemia, which amplifies ischemia-reperfusion injury via a reactive oxygen species-damage-associated molecular pattern-cytokine-endothelial cascade, increasing the risk of microvascular dysfunction and delayed graft function. This study developed an objective po...

Obesity is a global health and economic burden that affects disadvantaged groups and increases healthcare use. It involves adipocyte hypertrophy/hypoxia, adipokine imbalance, immune cell recruitment, pro-inflammatory polarization, signaling activation, systemic inflammation, oxidative stress, insulin resistance, and a higher cardiometabolic risk. This review synthesizes bariatric surgery as an ...

Acne vulgaris is a chronic inflammatory skin disease in which a defect in the immune barrier function is a major extent of the pathological etiology. The aim of this randomized controlled trial was to assess the restorative benefits of supramolecular salicylic acid (SSA) with intense pulsed light (IPL) photon rejuvenation and its effects on the immune barrier function of the skin in acne patien...

Inguinal hernia repair is performed over 20 million times annually, with outcomes reflecting mechanical reconstruction and immune activation. This study compared autoplasty and tension-free alloplasty for primary inguinal hernias, focusing on clinical outcomes and inflammatory responses. This prospective single-center study compared tissue-based autoplasty (Shouldice/Spasokukotsky) with tension...

Neoantigen-based personalized vaccines have emerged as an important innovation in the field of precision oncology through utilizing unique tumor somatic mutations to stimulate a targeted anti-tumor immune response. Unlike common tumor antigens, neoantigens can be recognized by the immune system as foreign because they exist only on tumor cells and thus do not contribute to any autoimmune reacti...

The co-circulation of dengue virus (DENV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in endemic regions poses significant immunological challenges, particularly in the context of cross-reactivity and vaccine design. Leveraging an in-silico pipeline, this study sought to identify conserved antigenic determinants between DENV serotype 1 (DENV-1) and SARS-CoV-2 that may under...

The study evaluates the relationship with diabetes self-management behavior and retinal microvascular status and hypothesizes whether HbA1c has an indirect statistically significant association between diabetes self-management behavior and retinal microvascular status in individuals with type 2 diabetes. The second view is to determine whether the involvement of continuous glucose monitoring is...

Autoimmune manifestations of primary minor immunodeficiencies (PMDs)—highly prevalent conditions that may represent a population-level model of autoimmunity—have not been systematically analyzed. The study aims to evaluate the current evidence for associations between PMDs and autoimmune syndromes. A systematic search of PubMed (MEDLINE) for 1980–2025 was conducted using keywords related to PMD...