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Correlation between “White Line” of Pharyngeal PosteriorWall and Laryngopharyngeal Reϐlux Disease

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https://doi.org/10.54963/entu.v14i3.837
Junfang Xue, Lihong Zhou, & Hongguang Guo. (2024). Correlation between “White Line” of Pharyngeal PosteriorWall and Laryngopharyngeal Reϐlux Disease. ENT Updates, 14(3). https://doi.org/10.54963/entu.v14i3.837
Volume 14 Issue 3 (2024)
Copyright (c) 2024 Junfang Xue, Lihong Zhou, Hongguang Guo
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

Objective: To explore the relationship between the “white line” of the posterior pharyngeal wall and laryngopharyngeal reflux disease (LPRD). Methods: The subjects were examined by fiberlaryngoscopy, and RSI and RFS scores were performed. The posterior pharyngeal wall was observed to determine the “white line”, the mucosal boundary between the nasopharynx and oropharynx. Results: There was a significant difference in RFS values of the three types of white lines (P = 0.017), and the significant difference was between type I and III (P = 0.006). Age, gender, RSI, and RFS were included to construct the ordered multi-classification logistics regression equation. The effect of RFS on the white line was statistically significant (OR = 0.8, 95%CI −0.326～−0.053, P = 0.008). Conclusions: The “white line”—the mucosal boundary between nasopharynx and oropharynx—has a correlation with laryngopharyngeal reflux.

Keywords:

“White Line” Throat Reϐlux Disease RSI RFS

References

  1. Vakil, N.; van Zanten, S.V.; Kahrilas, P.; et al. The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence Based Consensus. Am. J. Gastroenterol. 2006, 101, 1125–1140.
  2. Koufman, J.; Sataloff, R.T.; Toohill, R. Laryngopharyngeal Reflux: Consensus Conference Report. J. Voice 1996, 10, 215–216.
  3. Belafsky, P.C.; Postma, G.N.; Koufman, J.A．Validity and Reliability of the Reflux Symptom Index (RSI)．J. Voice 2002, 16, 274–277．
  4. Belafsky, P.C.; Postma, G.N.; Koufman, J.A. The Validity and Reliability of the Reflux Finding Score (RFS)．Laryngoscope 2001, 111, 1313–1317．
  5. Li, J.; Zhang, L.; Zhang, C.; et al. Linguistic Adaptation, Reliability, Validation, and Responsivity of the Chinese Version of Refux Symptom Index. J. Voice 2016, 30, 104–108.
  6. Mishra, P.; Agrawal, D.; Chauhan, K.; et al. Prevalence of Laryngopharyngeal Reflux Disease in Indian Population. Indian J. Otolaryngol. Head Neck Surg. 2022, 74, 1877–1881.
  7. Xiao, S.; Li, J.; Zheng, H.; et al. An Epidemiological Survey of Laryngopharyngeal Reflux Disease at the Otorhinolaryngology-Head and Neck Surgery Clinics in China. Eur. Arch. Otorhinolaryngol. 2020, 277, 2829–2838.
  8. Koufman, J.A.; Amin, M.R.; Panetti, M. Prevalence of Reflux in 113 Consecutive Patients with Laryngeal and Voice Disorders. Otolaryngol. Head Neck Surg. 2000, 123, 385–388.
  9. Brunworth, J.D.; Mahboubi, H.; Garg, R.; et al. Nasopharyngeal Acid Reflux and Eustachian Tube Dysfunction in Adults. Ann. Otol. Rhinol. Laryngol. 2014, 123, 415–419.
  10. Keles, B.; Ozturk, K.; Arbag, H.; et al. Frequency of Pharyngeal Reflux in Children with Adenoid Hyperplasia. Int. J. Pediatr. Otorhinolaryngol. 2005, 69, 1103–1107.
  11. O’Reilly, R.C.; He, Z.; Bloedon, E.; et al. The Role of Extraesophageal Reflux in Otitis Media in Infants and Children. Laryngoscope 2008 , 118, 1–9.
  12. Neri, G.; Pugliese, M.; Castriotta, A.; et al. White-Line: A New Finding in Laryngopharyngeal Reflux Objective Evaluation. Med. Hypotheses. 2013, 80, 769–772.
  13. Szczesniak, M.M.; Williams, R.B.; Cook, I.J. Mechanisms of Esophago-Pharyngeal Acid Regurgitation in Human Subjects. PLoS ONE 2011, 6, e22630.
  14. Postma, G.N.; Tomek, M.S.; Belafsky, P.C.; et al. Esophageal Motor Function in Laryngopharyngeal Reflux is Superior to That in Classic Gastroesophageal Reflux Disease. Ann. Otol. Rhinol. Laryngol. 2001, 110, 1114–1116.
  15. Schreiber, S.; Garten, D.; Sudhoff, H. Pathophysiological Mechanisms of Extraesophageal Reflux in Otolaryngeal Disorders. Eur. Arch. Otorhinolaryngol. 2009, 266, 17–24.
  16. Niu, K.; Guo, C.; Teng, S.; et al. Pepsin Promotes Laryngopharyngeal Neoplasia by Modulating Signaling Pathways to Induce Cell Proliferation. PLoS ONE 2020, 15, e0227408.
  17. Shaker, R., Bardan, E., Gu, C., et al. Intrapharyngeal Distribution of Gastric Acid Refluxate. Laryngoscope 2003, 113, 1182–1191.