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Clinical Research

An investigation of 8-hydroxy-2’-deoxyguanosine and 8-isoprostaglandin F2α levels in patients with larynx carcinoma

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https://doi.org/10.32448/entupdates.744725
Said Çetin, Y., Düzenli, U., Berköz, M., Özkan, H., & Bozan, N. (2020). An investigation of 8-hydroxy-2’-deoxyguanosine and 8-isoprostaglandin F2α levels in patients with larynx carcinoma. ENT Updates, 10(2). https://doi.org/10.32448/entupdates.744725
Volume 10 Issue 2 (2020)
Copyright (c) 2020 Yaser Said Çetin, Ufuk Düzenli, Mehmet Berköz, Hüseyin Özkan, Nazım Bozan
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Yaser Said Çetin
    Department of Otorhinolaryngology, Faculty of Medicine, Van Yüzüncü Yıl University, Van
  • Ufuk Düzenli Department of Otorhinolaryngology, Faculty of Medicine, Van Yüzüncü Yıl University, Van
  • Mehmet Berköz Department of Biochemistry, Faculty of Medicine, Van Yüzüncü Yıl University, Van
  • Hüseyin Özkan Department of Otorhinolaryngology, Faculty of Medicine, Van Yüzüncü Yıl University, Van
  • Nazım Bozan Department of Otorhinolaryngology, Faculty of Medicine, Van Yüzüncü Yıl University, Van

Objective: 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin F2α (8-iso-PGF2α) are indicators of oxidative stress in the human body. The aim of the present study was to investigate serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma and to compare them with healthy controls.

Methods: A total of 50 patients, consisting of 25 patients with larynx carcinoma (study group) and 25 healthy subjects (control group), were enrolled in the present study. Serum 8-OHdG concentration was measured using an ELISA kit, whereas an enzyme immunoassay kit was utilized for the measurement of serum 8-iso-PGF2α levels. TNM stages of the patients were recorded from the patient records in the study group.

Results: 8-OHdG and 8-iso-PGF2α levels were significantly higher in patients with larynx carcinoma than the control subjects. 8-OHdG levels were significantly higher in patients with LN metastases than the patients without LN metastases in the study group.

Conclusion: The findings of the present study showed the presence of significantly increased serum 8-OHdG and 8-iso-PGF2α levels in patients with larynx carcinoma, which may support the role of oxidative stress in the development laryngeal cancers.

Keywords:

Larynx cancer oxidative stress 8-hydroxy-2′-deoxyguanosine prostaglandin F2 alpha