ENT Updates

Experimental Study

Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study

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https://doi.org/10.2399/jmu.2017002008
Durmuş, K., Bora, A., Doğan, M., Özer, H., Tuncer, E., & Elif Altuntaş, E. (2017). Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study. ENT Updates, 7(2). https://doi.org/10.2399/jmu.2017002008
Volume 7 Issue 2 (2017)
Copyright (c) 2017 Kasım Durmuş, Adem Bora, Mehtap Doğan, Hatice Özer, Ersin Tuncer, Emine Elif Altuntaş
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Kasım Durmuş
    Department of Otolaryngology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
  • Adem Bora Department of Otolaryngology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
  • Mehtap Doğan Department of Otolaryngology, Yozgat City Hospital, Sivas, Turkey
  • Hatice Özer Department of Pathology, Faculty of Medicine, Cumhuriyet University Sivas, Turkey
  • Ersin Tuncer Department of Pathology, Faculty of Medicine, Cumhuriyet University Sivas, Turkey
  • Emine Elif Altuntaş Department of Otolaryngology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey

Objective: The aim of the present pilot study was to evaluate the effects of a single local dose administration of humic acid on healing of subcondylar mandibular fractures in rats.
Methods: In this study, a randomized experimental protocol was used. The study was conducted with 16 male Wistar-albino rats that were 16–18 weeks old. The rats (n=16) were randomly divided into two groups: Group HA received humic acid (0.3 cc/site, n=8) and Group C received no additional medical administration (control group, n=8). A full-thickness surgical osteotomy was performed in the subcondylar area. A single dose of humic acid (0.3 cc/site) was administered locally by spraying on the bone surfaces of the fracture line. Mandible was dissected on postoperative day 21. Then, fractured hemimandibles were obtained for histopathological examination.
Results: The median score of bone fracture healing was 7.16 (range: 7 to 8) in the Group HA and 7.50 (range: 7 to 8) in the Group C. When the groups were compared in terms of bone healing scores, there was no statistical difference between the Group HA and the Group C (p>0.05).
Conclusion: Results of this study showed that local administration of humic acid was not efficient for healing of bone fractures. However, we are of the opinion that it is required to conduct more comprehensive studies, including humic acid’s different concentrations and administration manners, evaluating the effects of humic acid on tissue both histopathologically
and in terms of inflammatory and proinflammatory cytokine levels.

Keywords:

Humic acid subcondylar mandibular fractures fracture healing