ENT Updates

Experimental Study

The effect of nimodipine and prednisolone on traumatic facial nerve injury treatment

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https://doi.org/10.2399/jmu.2017001011
Dölen, T., Kaygusuz, İrfan, Akpolat, N., Cengiz Alpay, H., Keleş, E., Karlıdağ, T., Yalçın, Şinasi, & Yüksel, K. (2017). The effect of nimodipine and prednisolone on traumatic facial nerve injury treatment. ENT Updates, 7(1). https://doi.org/10.2399/jmu.2017001011
Volume 7 Issue 1 (2017)
Copyright (c) 2017 Tolga Dölen, İrfan Kaygusuz, Nusret Akpolat, Hayrettin Cengiz Alpay, Erol Keleş, Turgut Karlıdağ, Şinasi Yalçın, Koray Yüksel
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Tolga Dölen Department of ORL, Faculty of Medicine, Fırat University, Elazığ, Turkey
  • İrfan Kaygusuz Department of ORL, Faculty of Medicine, Fırat University, Elazığ, Turkey
  • Nusret Akpolat Department of Pathology, Faculty of Medicine, İnönü University, Malatya, Turkey
  • Hayrettin Cengiz Alpay
    Department of ORL, Faculty of Medicine, Istanbul Kemerburgaz University, Istanbul, Turkey
  • Erol Keleş Department of ORL, Faculty of Medicine, Fırat University, Elazığ, Turkey
  • Turgut Karlıdağ Department of ORL, Faculty of Medicine, Fırat University, Elazığ, Turkey
  • Şinasi Yalçın Department of ORL, Faculty of Medicine, Fırat University, Elazığ, Turkey
  • Koray Yüksel Department of ORL, Faculty of Medicine, Fırat University, Elazığ, Turkey

Objective: To investigate the histopathological effect of nimodipine and prednisolone treatment on an animal model with peripheral facial nerve paralysis generated by clamping.
Methods: Twenty-eight New Zealand originated rabbits with facial nerve paralysis of the buccal branches generated by clamping were divided into four groups of seven each, administered with nimodipine, methylprednisolone and nimodipine-methylprednisolone combination throughout 21 days. The injured neural tissues were investigated histopathologically after treatment regarding perineural fibrosis, collagen degeneration, axonal degeneration, myelin degeneration, Schwann cell proliferation, normal myelin structure, and edema. The groups were compared with each other and with the control group.
Results: Statistically significant difference was determined between nimodipine and control groups regarding increased number of collagen fibers, myelin degeneration, axonal degeneration and myelin structure; between nimodipine and methylprednisolone groups, and between nimodipine and nimodipine-methylprednisolone combination groups regarding edema (p<0.05). Statistically significant data were also found between methylprednisolone and control groups in terms of increased number of collagen fibers, myelin degeneration, axonal degeneration and edema; between nimodipine-methylprednisolone combination and the control groups in terms of increased number of collagen fibers, myelin degeneration, axonal degeneration, normal myelin structure and edema (p<0.05).
Conclusion: Nimodipine and methylprednisolone both have positive effects on traumatic peripheral nerve paralysis with nerve integrity preserved whereas advantage of nimodipine over methylprednisolone cannot be suggested.

Keywords:

Facial nerve paralysis nimodipine methylprednisolone