ENT Updates

Case Report

Interesting 54 months survival after platinum based induction chemotherapy regimen alone in a patient with T2N0M0 supraglottic carcinoma

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https://doi.org/10.2399/jmu.2012003008
Kezban Gürbüz, M., Çaklı, H., Dinçer, M., Ediz, D., Dündar, E., & Özüdoğru, E. (2012). Interesting 54 months survival after platinum based induction chemotherapy regimen alone in a patient with T2N0M0 supraglottic carcinoma. ENT Updates, 2(3). https://doi.org/10.2399/jmu.2012003008
Volume 2 Issue 3 (2012)
Copyright (c) 2012 Melek Kezban Gürbüz, Hamdi Çaklı, Murat Dinçer, Durmuş Ediz, Emine Dündar, Erkan Özüdoğru
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Melek Kezban Gürbüz
    Department of Otolaryngology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey
  • Hamdi Çaklı Department of Otolaryngology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey
  • Murat Dinçer Department of Medical Oncology, Acıbadem Hospital, Eskişehir, Turkey
  • Durmuş Ediz Department of Radiation Oncology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey
  • Emine Dündar Department of Pathology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey
  • Erkan Özüdoğru Department of Otolaryngology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey

The conventional treatment modalities are surgery and/or radiation therapy in patients with early stage squamous cell carcinoma of the supraglottic larynx. In the literature, there are different opinions about the success of chemotherapy regimens with curative or inductive intent in patients with early stage laryngeal carcinoma. In this case report, a patient with T2N0M0 squamous cell carcinoma of the supraglottic larynx who presented with local recurrence and regional metastasis after a 54 months of non-followed period which follows two courses of cisplatinum/5-FU induction chemotherapy alone was presented. The beneficial effects of the induction chemotherapy in patients with early stage laryngeal carcinoma are doubtful. However, this regimen may be useful to estimate the possible success of radiotherapy by counseling with the patients who initially refused the conservative partial laryngectomy and with their families.

Keywords:

Larynx supraglottic carcinoma cisplatin 5-fluorouracil induction chemotherapy