Oral and Intestinal Microbiocenosis in Children with Erosive and Ulcerative Oral Diseases

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Oral and Intestinal Microbiocenosis in Children with Erosive and Ulcerative Oral Diseases

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https://doi.org/10.54963/entu.v15i3.1381
Kozhonazarova, G., Uzakov, O., Alymbaev, E., Sulaymanov, S., Malevannaya, V., Terekhova, O., Ongoyeva, B., Abdurakhmanov A.A., A., Umashev, S., Akmatova, A., Chubakova, B., Melisbekova, A., & Vityala, Y. (2025). Oral and Intestinal Microbiocenosis in Children with Erosive and Ulcerative Oral Diseases. ENT Updates, 15(3), 63–72. https://doi.org/10.54963/entu.v15i3.1381
Volume 15 Issue 3 (2025): In Progress
Copyright (c) 2025 Gulsara Kozhonazarova, Orozali Uzakov, Erkin Alymbaev, Shayirbek Sulaymanov, Valeria Malevannaya, Oksana Terekhova, Bermet Ongoyeva, Almaz Abdurakhmanov A.A., Samat Umashev, Altynai Akmatova, Baktygul Chubakova, Aliya Melisbekova, Yethindra Vityala
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Authors

  • Gulsara Kozhonazarova

    Science and Analytical Department, International Higher School of Medicine, Bishkek 720054, Kyrgyzstan
    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
  • Orozali Uzakov

    Science and Analytical Department, International Higher School of Medicine, Bishkek 720054, Kyrgyzstan
  • Erkin Alymbaev

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
  • Shayirbek Sulaymanov

    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Valeria Malevannaya

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Oksana Terekhova

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
  • Bermet Ongoyeva

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Almaz Abdurakhmanov A.A.

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Samat Umashev

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Altynai Akmatova

    Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek 720020, Kyrgyzstan
    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Baktygul Chubakova

    Department of Science, National Center for Maternity and Childhood Care, Bishkek 720000, Kyrgyzstan
  • Aliya Melisbekova

    Science and Analytical Department, International Higher School of Medicine, Bishkek 720054, Kyrgyzstan
  • Yethindra Vityala

    Department of Pathology, International Higher School of Medicine, Bishkek 720054, Kyrgyzstan

Erosive and ulcerative oral diseases, such as recurrent aphthous stomatitis and herpetiform ulcers, are common in children and significantly affect their quality of life. This observational study investigated the relationship between oral and intestinal microbiocenosis and the onset of these conditions in 648 children aged 1–16 years. Microbiological examination revealed dysbiotic changes in the oral and gut microbiota of affected children compared to controls, with a significant decrease in beneficial commensal bacteria, particularly Bifidobacterium and Lactobacillus species, and an increase in opportunistic pathogens, such as Staphylococcus and Candida spp. The reduction in Bifidobacteria and Lactobacilli in both oral and stool samples supports the concept of a gut-oral microbial axis in the manifestation of these diseases. These findings suggest that systemic factors, such as intestinal microbial imbalance, may contribute to the development of recurrent oral lesions in children. Incorporating microbiota analysis into the diagnostic process and considering targeted treatments, such as probiotics and dietary adjustments, could improve clinical outcomes. This study emphasizes the importance of a multidisciplinary approach involving collaboration among ENT specialists, pediatric dentists, gastroenterologists, and microbiologists to comprehensively evaluate and manage these conditions in children. Further research is needed to elucidate the causal relationships between microbial shifts and disease flares and to develop personalized microbiota-based interventions for pediatric patients with erosive and ulcerative oral diseases.

Keywords:

Recurrent Aphthous Stomatitis Herpetiform Ulcers Oral Microbiota Gut Microbiota Pediatric Dysbiosis

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