Objective: To evaluate the antitumor effect of cetuximab as a single agent for the treatment of oral cavity cancers and to clarify the dosedependent growth inhibitory effect in oral cavity squamous cell carcinoma cell line (OCSCCCL).
Methods: The OCSCCCL (UPCI-SCC131) were cultured and continuously monitored using the xCELLigence RTCA SP instrument. The...
Objective: To determine the efficacy of systemic administration of coenzyme Q10 at low and high doses on cisplatin-induced ototoxicity in rats.
Methods: Our study was performed with 40 Sprague-Dawley rats. They were divided randomly into five groups: Cis, Cis+Q1030, Cis+Q1010, Q10, and control. Cis (n=8) group was administered cisplatin [a single intrap...
Objective: To investigate the healing effects of topical dexpanthenol on acute tympanic membrane (TM) perforations in rats through observations of healing time and histopathological changes.
Methods: A total of 20 Sprague-Dawley rats were included in the study. Every perforation was formed at the pars tensa of TMs with a size 2 mm in diameter. The right...
Objective: The aim of this study was to determine the relationship between polymorphisms of endothelial nitric oxide synthase (eNOS) and myeloperoxidase (MPO) genes and development of microtia.
Methods: Nineteen (11 males, 8 females) unrelated cases with microtia and 40 healthy controls were enrolled in the present study. The study focused on three func...
Objective: The aim of this study was to investigate whether mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can be used as inflammation markers in selection of pediatric patients, who were planned to undergo tonsillotomy for sleep apnea, or not.
Methods: The tonsillotomy group consisted of pediatric pati...
Objective: Acute infection of the parotid gland is common in the clinical practice of ear-nose-throat medicine. The present study aims to demonstrate the effect of parotid gland massage on serum amylase levels.
Methods: The study included 30 patients with acute parotitis presenting to our clinic and 14 healthy volunteers. The correlation between the ser...
Objective: We aimed to investigate the frequency of incidental diagnosis of paranasal sinus and mastoid abnormalities on brain magnetic resonance imaging (MRI) and its correlation with symptoms of patients.
Methods: We examined 100 patients who underwent brain MRI due to several different complaints other than sinusitis and mastoiditis. The patients who...
Objective: Nowadays, psoriasis is accepted to be an autoinflammatory/ autoimmune disease. As a result of chronic inflammation, psoriasis is widely investigated for associated diseases and comorbidities. However, there are limited data about the effects of psoriasis on hearing functions. The aim of the study was to investigate prospectively if patients with psoriasis have sensor...
Objective: There are many factors considered to be related with the etiology of sudden sensorineural hearing loss (SSNHL) such as viral infections, microvascular diseases and inflammation. Increased mean platelet volume (MPV) levels are assumed to represent more active enzymatic process and thrombotic predisposition. Our aim in this study is to show whether MPV could be a predi...
Sialolithiasis is a condition characterized by the obstruction of salivary gland or its excretory duct by a calculus or sialolith. This condition provokes swelling, pain, and infection of affected gland leading to salivary ectasia and even causing the subsequent dilatation of the salivary gland. The aim of this case report is to present a rare condition of sialolithiasis of the submandibular gl...
