Submission Deadline: March 31, 2026

Guest Editor:

Dr. Khalid Sossey-Alaoui  
Department of Molecular Medicine, School of Medicine, Case Western Reserve University

 

Special Issue Information:

Dear Colleagues,

This collection of manuscripts is intended to highlight the rapidly evolving landscape of immuno-oncology, bringing together cutting-edge research that spans fundamental mechanisms, translational advances, and novel therapeutic strategies. As the field continues to redefine cancer treatment paradigms, these studies will collectively underscore the pivotal role of the immune system in recognizing and eliminating malignant cells, as well as the complex mechanisms by which tumors evade immune surveillance.

Key themes in this collection will include the development and refinement of immune checkpoint inhibitors, CAR-T cell therapies, and bispecific antibodies, along with deeper insights into the tumor microenvironment, immune resistance pathways, and biomarkers of response. While some manuscripts will explore emerging targets beyond PD-1/PD-L1 and CTLA-4, and delve into the role of myeloid cells, regulatory T cells, and stromal components in shaping antitumor immunity, others will examine the therapeutic potential of modulating innate immunity, cancer vaccines, and personalized neoantigen-based strategies.

A common thread across these contributions will be the translational bridge between preclinical models and clinical application. From novel combination therapies to strategies that enhance immune cell trafficking and persistence, this collection will showcase innovations designed to improve both efficacy and durability of response in patients with solid and hematologic malignancies. This collection will also emphasize the importance of biomarker-driven approaches for patient stratification, treatment optimization, and resistance monitoring. By integrating genomic, transcriptomic, and proteomic profiling, these studies offer a blueprint for more precise and personalized immunotherapies.

Together, this collection will provide a comprehensive view of current challenges and future opportunities in immuno-oncology. They will offer not only a state-of-the-art understanding of tumor-immune dynamics, but will also chart a course toward more effective, safer, and patient-tailored cancer immunotherapies.

Guest Editor(s)
Dr. Khalid Sossey-Alaoui

Keywords:

• Triple negative breast cancer
• Immune evasion
• Tumor microenvironment
• PD-L1
• CAR-T
• Multi-Omics
• Metastasis microenvironment
• Bioinformatics