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Editorial

The Nobel Prize in Physiology or Medicine 2023 was awarded for discoveries concerning base modifications that enabled the development of effective mRNA vaccines against COVID-19

Fukumi Furukawa
    Received: 06 September 2024
    Published: 18 February 2024

    Abstract

      

    References

    1. 1. Available online: https://www.nobelprize.org/prizes/medicine/2023/press-release/ (accessed on 18 October 2023).
    2. 2. Available online: https://www.nobelprize.org/prizes/medicine/2023/summary/ (accessed on 18 October 2023).
    3. 3. Karikó K, Buckstein M, Ni H, et al. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA. Immunity. 2005, 23(2): 165-175. doi: 10.1016/j.immuni.2005.06.008
    4. 4. Karikó K, Muramatsu H, Welsh FA, et al. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability. Molecular Therapy. 2008, 16(11): 1833-1840. doi: 10.1038/mt.2008.200
    5. 5. Anderson BR, Muramatsu H, Nallagatla SR, et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Research. 2010, 38(17): 5884-5892. doi: 10.1093/nar/gkq347
    6. 6. Kayano T, Sasanami M, Kobayashi T, et al. Number of averted COVID-19 cases and deaths attributable to reduced risk in vaccinated individuals in Japan. The Lancet Regional Health - Western Pacific. 2022, 28: 100571. doi: 10.1016/j.lanwpc.2022.100571
    7. 7. Lamprinou M, Sachinidis A, Stamoula E, et al. COVID-19 vaccines adverse events: potential molecular mechanisms. Immunologic Research. 2023, 71(3): 356-372. doi: 10.1007/s12026-023-09357-5
    8. 8. Ogata AF, Cheng CA, Desjardins M, et al. Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clinical Infectious Diseases. 2021, 74(4): 715-718. doi: 10.1093/cid/ciab465
    9. 9. Ghaderi S, Mohammadi S. Post-COVID-19 vaccination and the brain: A critical analysis of CNS MRI findings. Trends in Immunotherapy. 2023, 7(2): 2885. doi: 10.24294/ti.v7.i2.2885
    10. 10. Ishikawa O. The pathophysiology and clinical phenotypes of COVID-19 mRNA vaccine-related cutaneous adverse reactions: A narrative review. Trends in Immunotherapy [in press].
    11. 11. Matsuo A, Nakashima C, Yanagihara S, et al. Two cases of COVID-19 vaccine-related erythema multiforme under the administration of immune checkpoint inhibitors. Trends in Immunotherapy. 2023, 7(2): 2683. doi: 10.24294/ti.v7.i2.2683
    12. 12. Furukawa F. The Nobel Prize in Physiology or Medicine 2018 was awarded to Cancer Therapy by Inhibition of Negative Immune Regulation. Trends in Immunotherapy. 2018, 2(1). doi: 10.24294/ti.v2.i1.1065
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