Article

A pilot study of diet lifestyle on complete blood picture, elements, and biological profile in females

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Felemban, S., & Fathi Hamouda, A. (2024). A pilot study of diet lifestyle on complete blood picture, elements, and biological profile in females. Trends in Immunotherapy, 8(2). https://doi.org/10.24294/ti.v8.i2.6766

Authors

  • Shifa Felemban Department of Chemistry, Faculty of Applied Science, University College-Al Leith, University of Umm Al-Qura, Makkah 21955, Saudi Arabia
  • Asmaa Fathi Hamouda
    Department of Biochemistry, Faculty of Science, University of Alexandria, Alexandria 21111, Egypt

Obesity, a prevalent global health issue, is characterized by elevated lipid levels, altered hematological parameters, inflammation, and other related symptoms. A biological profile and complete blood count (CBC) are essential tools for assessing overall health and detecting various dysfunctions, including anemia, infections, leukemia, and heart diseases. In obese patients of both sexes, a high white blood cell count is a reliable indicator of leukemia risk, coronary complications, and inflammation. Notably, dietary and lifestyle changes can significantly improve obesity-related conditions and hematological disorders. This study examines the effects of a six-month dietary program on anthropometric measurements, biological profiles, elemental composition, and complete blood counts in 43 obese females with white blood cell counts above the normal range. Participants underwent comprehensive hematological, biochemical, and anthropometric assessments at the beginning and end of the diet program. The findings revealed a significant weight loss and substantial improvements in laboratory parameters and blood profiles. These improvements are likely due to the nutrient composition of the diet program. The investigation confirmed that modifying dietary intake by reducing consumption of high-acidic foods, fast foods, animal-derived lipids, refined carbohydrates, red meats, and non-seasonal produce, in favor of a nutrient-dense regimen comprising fruits, vegetables (consumed raw or steamed), fish, poultry, and whole grains, resulted in significant enhancements in hematological indices and biological markers. These enhancements substantially surpassed baseline measurements for complete blood count and biological profiles. However, alterations in the elemental profile were not statistically significant. Further studies are being conducted to examine these outcomes with greater specificity. Ongoing research aims to further understand these effects according to personal medical history, age, and sex.

Keywords:

anthropometric measurements biological profile complete blood count obesity diet elements

References

  1. Asmaa F. Hamouda, Saad El Dien A Abou El Noeman. Effects of 6-Month Weight Loss New Program on Anthropometric Measurements and Biological Profile. Journal of Pharmacy and Pharmacology. 2016; 4(1). doi: 10.17265/2328-2150/2016.01.005
  2. Fathi Hamouda A. Study the Association Between Diet Program on Human Semen, Biological Profile, and Anthropometric Measurements in Obese Men. International Journal of Nutrition and Food Sciences. 2018; 7(1): 24. doi: 10.11648/j.ijnfs.20180701.14
  3. Bhaskaran K, Douglas I, Forbes H, et al. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet. 2014; 384(9945): 755-65.
  4. Morrison KM, Shin S, Tarnopolsky M, et al. Association of depression & health related quality of life with body composition in children and youth with obesity. Journal of Affective Disorders. 2015; 172: 18-23. doi: 10.1016/j.jad.2014.09.014
  5. Trogdon JG, Finkelstein EA, Hylands T, et al. Indirect costs of obesity: a review of the current literature. Obesity Reviews. 2008; 9(5): 489-500. doi: 10.1111/j.1467-789x.2008.00472.x
  6. Hammond RA, Levine R. The economic impact of obesity in the United States. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2010; 3: 285-295. doi: 10.2147/dmso.s7384
  7. Moussoki JM, Kambourou J, Moulongo JGA, et al. Impact of Obesity on Hematological Parameters in Adolescents in Brazzaville, Congo. OALib. 2023; 10(4): 1-13. doi: 10.4236/oalib.1109816
  8. Abdul Hussein Jabbar M, Khidhair Hussain Z. Study of some physiological and hematological parameters in obese women with arthritis. Biomedicine. 2023; 43(1): 423-427. doi: 10.51248/.v43i01.2270
  9. Unruh D, Srinivasan R, Benson T, et al. Red Blood Cell Dysfunction Induced by High-Fat Diet. Circulation. 2015; 132(20): 1898-1908. doi: 10.1161/circulationaha.115.017313
  10. Bornfeldt KE, Tabas I. Insulin Resistance, Hyperglycemia, and Atherosclerosis. Cell Metabolism. 2011; 14(5): 575-585. doi: 10.1016/j.cmet.2011.07.015
  11. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nature Medicine. 2012; 18(3): 363-374. doi: 10.1038/nm.2627
  12. Gower RM, Wu H, Foster GA, et al. CD11c/CD18 Expression Is Upregulated on Blood Monocytes During Hypertriglyceridemia and Enhances Adhesion to Vascular Cell Adhesion Molecule-1. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31(1): 160-166. doi: 10.1161/atvbaha.110.215434
  13. Swirski FK, Libby P, Aikawa E, et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. Journal of Clinical Investigation. 2007; 117(1): 195-205. doi: 10.1172/jci29950
  14. Hamouda AF, Moustafa Hassan AA, Khardali IA, et al. A Screening Pilot Study on the Relation between Body Mass Index, and Heavy Metal and Mineral Levels in College Students. Electronic Journal of Biology. 2019; 15(3). doi: 10.36648/1860-3122.15.3.79
  15. Hamouda AF, Felemban S. A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices. Molecules. 2023; 28(14): 5582. doi: 10.3390/molecules28145582
  16. Deng CF, Zhu N, Zhao TJ, et al. Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential. Frontiers in Oncology. 2022; 12. doi: 10.3389/fonc.2022.803473
  17. Murai T. Cholesterol lowering: role in cancer prevention and treatment. Biological Chemistry. 2014; 396(1): 1-11. doi: 10.1515/hsz-2014-0194
  18. Huang B, Song B liang, Xu C. Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nature Metabolism. 2020; 2(2): 132-141. doi: 10.1038/s42255-020-0174-0
  19. Quintaes KD, Diez‐Garcia RW. The importance of minerals in the human diet. Handbook of Mineral Elements in Food. Published online February 20, 2015: 1-21. doi: 10.1002/9781118654316.ch1
  20. Van Tiel ED, Peeters Petra HM, Nagelkerke Nico JD, Smit Henriette A. Quitting smoking may restore hematological characteristics within five years. Ann Epidemiol. 2002; 12(6): 378-388. doi: 10.1016/S1047-2797(01)00282-4
  21. Lee G, Arcasoy MO. The clinical and laboratory evaluation of the patient with erythrocytosis. European Journal of Internal Medicine. 2015; 26(5): 297-302. doi: 10.1016/j.ejim.2015.03.007
  22. Asmaa HF. The challenge from silence to stand up, 1st ed. Available online: https://www.amazon.com/Challenge-Silence-Stand-Up/dp/1934502227?ref_=ast_author_dp (accessed on 17 February 2023)
  23. Tefferi A, Barbui T. Essential Thrombocythemia and Polycythemia Vera: Focus on Clinical Practice. Mayo Clinic Proceedings. 2015; 90(9): 1283-1293. doi: 10.1016/j.mayocp.2015.05.014
  24. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. The American Journal of Gastroenterology. 2001; 96(3): 776-781. doi: 10.1111/j.1572-0241.2001.03621.x
  25. Deska Pagana K, Pagana TJ, Pagana TN. Mosby’s Diagnostic and Laboratory Test Reference, 12th ed. Elsevier. 2015.
  26. Hoffmann JJML. Reticulated platelets: analytical aspects and clinical utility. Clinical Chemistry and Laboratory Medicine (CCLM). 2014; 52(8). doi: 10.1515/cclm-2014-0165
  27. Ohshita K, Yamane K, Hanafusa M, et al. Elevated White Blood Cell Count in Subjects With Impaired Glucose Tolerance. Diabetes Care. 2004; 27(2): 491-496. doi: 10.2337/diacare.27.2.491
  28. Tong PC, Lee KF, So WY, et al. White Blood Cell Count Is Associated With Macro- and Microvascular Complications in Chinese Patients With Type 2 Diabetes. Diabetes Care. 2004; 27(1): 216-222. doi: 10.2337/diacare.27.1.216
  29. Ruggiero C, Metter EJ, Cherubini A, et al. White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging. Journal of the American College of Cardiology. 2007; 49(18): 1841-1850. doi: 10.1016/j.jacc.2007.01.076
  30. IJsselmuiden AJ, Musters RJ, de Ruiter G, et al. Circulating white blood cells and platelets amplify oxidative stress in heart failure. Nature Clinical Practice Cardiovascular Medicine. 2008; 5(12): 811-820. doi: 10.1038/ncpcardio1364
  31. Someya Y, Tanihata J, Sato S, et al. Zinc-Deficiency Induced Changes in the Distribution of Rat White Blood Cells. Journal of Nutritional Science and Vitaminology. 2009; 55(2): 162-169. doi: 10.3177/jnsv.55.162
  32. Nagareddy PR, Kraakman M, Masters SL, et al. Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity. Cell Metabolism. 2014; 19(5): 821-835. doi: 10.1016/j.cmet.2014.03.029
  33. Ledikwe JH, Blanck HM, Khan LK, et al. Low-Energy-Density Diets Are Associated with High Diet Quality in Adults in the United States. Journal of the American Dietetic Association. 2006; 106(8): 1172-1180. doi: 10.1016/j.jada.2006.05.013
  34. Marx W, McKavanagh D, McCarthy AL, et al. The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review. Freson K, ed. PLOS ONE. 2015; 10(10): e0141119. doi: 10.1371/journal.pone.0141119
  35. Abrokwah FK, Asamoah KA, Esubonteng PKA. Effects of the intake of natural cocoa powder on some biochemical and haematological indices in the rat. Ghana Med J. 2009; 43(4): 164-168.
  36. Hamouda AF, Felemban S. A Pilot Study of the Amelioration of Avocado Seed Oil in Obese Female Rats Induced by Carbon Tetrachloride and Alloxan Monohydrate. J Drug Alcohol Res. 2022; 11: 1-13. doi: 10.4303/jdar/236177
  37. Felemban S, Hamouda AF. A Pilot Study of the Effects of Ajwa Date Seed Extract in a Diabetic Animal with Parallel Observations on Human Subjects. Journal of Pharmaceutical Research International. 2022; 23-33. doi: 10.9734/jpri/2022/v34i38a36214
  38. Nassan M, Mohamed E, Abdelhafez S, et al. Effect of clove and cinnamon extracts on experimental model of acute hematogenous pyelonephritis in albino rats: Immunopathological and antimicrobial study. International Journal of Immunopathology and Pharmacology. 2015; 28(1): 60-68. doi: 10.1177/0394632015572075
  39. Nandakumaran M, Al-Sannan B, Al-Dossery M, Al-Shammari M. Effect of Olive Oil Administration on Certain Hematologic and Metabolic Parameters in Pregnant Rats. International Journal of Pure &Apllied Bioscience. 2014; 2(4): 93-99.
  40. Singh I, Mok M, Christensen AM, et al. The effects of polyphenols in olive leaves on platelet function. Nutrition, Metabolism and Cardiovascular Diseases. 2008; 18(2): 127-132. doi: 10.1016/j.numecd.2006.09.001
  41. Roayaei M, Mansouri-Tehrani HA, Rabbani-Khorasgani M, et al. Effect of supplements: Probiotics and probiotic plus honey on blood cell counts and serum IgA in patients receiving pelvic radiotherapy. Journal of Research in Medical Sciences. 2015; 20(7): 679. doi: 10.4103/1735-1995.166224
  42. Dar A, Singh S, Palod J, et al. Effect of Probiotic, Prebiotic and Synbiotic on Hematological Parameters of Crossbred Calves. International Journal of Livestock Research. Published online 2017: 1. doi: 10.5455/ijlr.20170312053224
  43. Duttaroy AK, Jørgensen A. Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers. Platelets. 2004; 15(5): 287-292. doi: 10.1080/09537100410001710290
  44. Hamouda AF, Hassan A. A Short Communication Pilot Study on Stress and Its Chronic Consequences of College Students. CPQ Nutrition. 2020; 4(2): 1-12.
  45. Hamouda AF, Shaban NZ. Short and Long Term Effects of Pomegranate (Punica Granatum) Extracts on Apoptosis in Rat Kidney Induced by Diethylnitrosamine and Phenobarbital. Journal of Pharmacy and Pharmacology. 2016; 4(2): 52-63. doi: 10.17265/2328-2150/2016.02.002
  46. Hamouda AF, Felemban S. Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study. Molecules. 2023; 28(2): 903. doi: 10.3390/molecules28020903
  47. Gharibzahedi SMT, Jafari SM. The importance of minerals in human nutrition: Bioavailability, food fortification, processing effects and nanoencapsulation. Trends in Food Science & Technology. 2017; 62: 119-132. doi: 10.1016/j.tifs.2017.02.017
  48. IOM (Institute of Medicine). Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. National Academies Press; 2005. doi: 10.17226/10925
  49. Levings JL, Gunn JP. The Imbalance of Sodium and Potassium Intake: Implications for Dietetic Practice. Journal of the Academy of Nutrition and Dietetics. 2014; 114(6): 838-841. doi: 10.1016/j.jand.2014.02.015
  50. Zhang F, Ye J, Zhu X, et al. Anti-Obesity Effects of Dietary Calcium: The Evidence and Possible Mechanisms. International Journal of Molecular Sciences. 2019; 20(12): 3072. doi: 10.3390/ijms20123072
  51. Alshwaiyat NM, Ahmad A, Al-Jamal HAN. Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial. Frontiers in Nutrition. 2023; 10. doi: 10.3389/fnut.2023.1155947
  52. Foster M, Chu A, Petocz P, et al. Effect of vegetarian diets on zinc status: a systematic review and meta‐analysis of studies in humans. Journal of the Science of Food and Agriculture. 2013; 93(10): 2362-2371. doi: 10.1002/jsfa.6179
  53. Pan S, Yan X, Tan B, et al. Effects of dietary zinc sources and levels on growth performance, serum biochemical and immunological indexes and tissue zinc content of Litopenaeus vannamei. Aquaculture Reports. 2022; 25: 101247. doi: 10.1016/j.aqrep.2022.101247
  54. Hamouda AF. Approach to Cope with Cancer Treatment: I Will Rise Again- Our Voices Must be Heard, 1st ed. BP International. doi: 10.9734/bpi/mono/978-81-97637