Trends in Immunotherapy

Case Report

Durable complete response to combination nivolumab and ipilimumab in metastatic renal cell carcinoma

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https://doi.org/10.24294/ti.v6.i1.1387
Takayasu, K., Muguruma, K., & Kinoshita, H. (2022). Durable complete response to combination nivolumab and ipilimumab in metastatic renal cell carcinoma. Trends in Immunotherapy, 6(1). https://doi.org/10.24294/ti.v6.i1.1387
Volume 6 Issue 1 (2022)

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Authors

  • Kenta Takayasu
    Department of Urology, Takatsuki Red Cross Hospital
  • Koei Muguruma
  • Hidefumi Kinoshita

Immune checkpoint inhibitors, which promote or suppress the anti-tumor immune response, are becoming the mainstay of cancer treatment. In 2018, CheckMate 214 study showed a higher response rate with ipilimumab and nivolumab combination therapy compared to conventional therapy for advanced renal cell carcinoma. We report a case of complete response and durable response for two years to ipilimumab and nivolumab combination therapy in a patient with postoperative renal cancer recurrence that caused immune-related adverse events such as interstitial pneumonia and hepatotoxicity.

Keywords:

Immune Checkpoint Inhibitor Ipilimumab Nivolumab Combination Therapy Advanced Renal Cell Carcinoma Durable Response Immune-related Adverse Events

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