Studies conducted on the chemical composition of the genus Trichilia have isolated and identified 334 different compounds such as monoterpenes, diterpenes, sesquiterpenes, triterpenes, limonoids, steroids, coumarins, lignans, flavonoids, amino acid, phenolic acids, and lactones. This genus is used in traditional medicine for the manufacture of antibacterial, antioxidant, antiviral and antimalarial drugs. Indeed, our research with numerous Trichilia species has revealed that these plants exhibit antioxidant, antibacterial, anticholinesterase, neuroprotective, anti-inflammatory, and anti-anaphylactic properties against pathogens of major clinical value. The properties of analgesia, liver protection, and immunomodulation are also being studied. This study summarizes the main therapeutic uses of Genus Trichilia of species mentioned in the article and encourages future research into their usage in the treatment of various ailments as antimicrobial and anticancer.