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Efficacy and Safety of Corticosteroid Treatments in Chronic Rhinosinusitis Management: A Systematic Review

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https://doi.org/10.54963/entu.v14i3.875
Wajan Alqathanin, Mohammed Kanan, Wajin Alruwili, Lama Alrasheedi, Bader Almutairi, Bayan Alghamdi, Moataz Hisham, Fajr Omar, Sahar Alasmari, Fahad Humoud, Mohammed Rughaylan, Mohammed Shayil, Hagris Naif, & Faisal Khalid. (2024). Efficacy and Safety of Corticosteroid Treatments in Chronic Rhinosinusitis Management: A Systematic Review. ENT Updates, 14(3). https://doi.org/10.54963/entu.v14i3.875
Volume 14 Issue 3 (2024)
Copyright (c) 2024 Wajan Alqathanin, Mohammed Kanan, Wajin Alruwili, Lama Alrasheedi, Bader Almutairi, Bayan Alghamdi, Moataz Hisham, Fajr Omar, Sahar Alasmari, Fahad Humoud, Mohammed Rughaylan, Mohammed Shayil, Hagris Naif, Faisal Khalid
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors

  • Wajan Alqathanin Department of Doctor of Pharmacy, College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia
  • Mohammed Kanan Department of Pharmacy, Rafha General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia
  • Wajin Alruwili
    Department of Pharmacy, Rafha General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia
  • Lama Alrasheedi Department of Doctor of Pharmacy, College of Pharmacy, Northern Border University, Rafha 76321, Saudi Arabia
  • Bader Almutairi Department of Doctor of Pharmacy, College of Pharmacy, Qassim University, Buraydah 52571, Saudi Arabia
  • Bayan Alghamdi Department of Doctor of Pharmacy, College of Pharmacy, Umm-Al-Qura University, Makkah 24382, Saudi Arabia
  • Moataz Hisham Department of Doctor of Pharmacy, College of Pharmacy, Umm-Al-Qura University, Makkah 24382, Saudi Arabia
  • Fajr Omar Department of Doctor of Pharmacy, College of Pharmacy, King Khalid University, Abha 62521, Saudi Arabia
  • Sahar Alasmari Pharmaceutical Care Department, Aseer Health Cluster, Abha 62521, Saudi Arabia
  • Fahad Humoud Department of Pharmacy, Rafha General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia
  • Mohammed Rughaylan Department of Pharmacy, Rafha General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia
  • Mohammed Shayil Department of Pharmacy, Rafha General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia
  • Hagris Naif Department of Medical Supply, Al Awayqilah General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia
  • Faisal Khalid Department of Pharmacy, Rafha General Hospital, Northern Border Health Cluster, Rafha 76321, Saudi Arabia

Chronic rhinosinusitis (CRS) is a prevalent inflammatory disorder of the nasal and paranasal sinus mucosa, affecting 5–15% of the global population. This systematic review evaluated the efficacy and safety of systemic, injectable, and intranasal corticosteroids (CS) for the treatment of CRS and its subtypes. A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science, focusing on studies published between 2010 and 2023. Six studies were finally included in the analysis. Systemic CS, particularly oral CS, significantly improved nasal congestion, reduced nasal polyp size, and enhanced the quality of life in the short term. However, their long-term use is discouraged because of side effects, such as insomnia and gastrointestinal issues. Injectable CS offer longer symptom relief and potentially lower adrenal suppression risk than oral forms, but data are limited. Intranasal CS are preferred because of their safety and efficacy in long-term maintenance therapy, with newer formulations offering increased potency and reduced systemic absorption This review highlights the importance of tailoring CS treatment based on CRS subtype, severity, and patient-specific factors. Future research should focus on optimizing CS delivery methods and exploring novel therapies to enhance the long-term management of CRS, while minimizing adverse effects.

Keywords:

Chronic Rhinosinusitis Corticosteroids Systemic Corticosteroids Injectable Corticosteroids Intranasal Corticosteroids

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