Generative Dialogue Agent Design for Research Integrity Education: Behavioral Intervention and Cognitive Training Evidence

Li You ORCID ,  Yongguo Hu ORCID ,  Zhipeng Li ORCID ,  Li Dai ORCID ,  Jie Zhao ORCID ,  Jie Liu ORCID ,  Wenjie Huang ORCID ,  Zonghui Wu ORCID ,  Yahui Li ORCID ,  Yongsong Yan ORCID

    Received: 9 February 2026; Revised: 18 March 2026; Accepted: 9 April 2026; Published: 19 May 2026

    Abstract

    Research integrity education may demonstrate that these programs establish critical foundations for maintaining healthy academic ecosystems. The traditional educational approaches might indicate limitations including insufficient interactivity and low personalization. Moreover, this study could examine a generative conversational agent system for research integrity education. The system appears to enhance integrity literacy through dual behavioral intervention mechanisms. The research employed a quasi-experimental design with 126 graduate students. Given that participants received random assignment into experimental and control groups, the experimental group participated in an eight-week agent-based intervention. The control group received traditional lecture-based training instead. Furthermore, we measured indicators at baseline, immediate post-intervention, and three-month follow-up points. These indicators may show cognition level, behavioral norms, moral reasoning ability, and critical thinking. The results could demonstrate that the significant experimental group showed greater improvements than the control group across all important indicators. Research integrity cognition might indicate increases by 25.5%. Notwithstanding these critical empirical findings, the important academic behavioral norms could be improved by 25.1% substantially. Nonetheless, several limitations warrant acknowledgment: the sample was drawn from a single institution, limiting generalizability; the three-month follow-up period may be insufficient to capture long-term behavioral transfer; and the system's performance in handling culturally nuanced or highly ambiguous ethical dilemmas remains suboptimal. These findings contribute empirical evidence for the application of generative artificial intelligence in professional ethics education while offering practical guidance for the intelligent transformation of research integrity training in academic institutions.

    Keywords

    References

    1. 1. Horbach, P.S.; Fishberg, R.; Ulpts, S.; et al. Thou Shalt Not!—How the institutional afterlife of research misconduct scandals shapes research integrity training. J. Responsible Innov. 2024, 11, 2414500. DOI: https://doi.org/10.1080/23299460.2024.2414500
    2. 2. Wang, P.; Jia, Y. Exploration and Practice of Research Integrity Education for Graduate Students in Universities in the Digital Intelligence Era. Pop. Lit. Art 2025, 135–137. DOI: https://doi.org/10.20112/j.cnki.ISSN1007-5828.2025.16.045 (in Chinese)
    3. 3. Francesca, G.; Ceruti, S.; Martini, S.; et al. Educating and Training in Research Integrity (RI): A Study on the Perceptions and Experiences of Early Career Researchers Attending an Institutional RI Course. J. Acad. Ethics 2023, 22, 413–430. DOI: https://doi.org/10.1007/S10805-023-09497-1
    4. 4. Dubbaka, S. Incorporating Implicit bias into research integrity education: Response to 'Why and how to incorporate issues of race/ethnicity and gender in research integrity education'. Account. Res. 2023, 32, 193–194. DOI: https://doi.org/10.1080/08989621.2023.2247974
    5. 5. Labib, K., Evans, N., Pizzolato, D.; et al. Co-creating Research Integrity Education Guidelines for Research Institutions. Sci. Eng. Ethics 2023, 29, 28. DOI: https://doi.org/10.1007/S11948-023-00444-2
    6. 6. Panpakdee, C.; Khanbut, K. Pathways to food security: Perceptions of resilience between organic farmers and extension agents in Thung Kala Ronghai, Thailand. Cogent Food Agric. 2025, 11, 2546989. DOI: https://doi.org/10.1080/23311932.2025.2546989
    7. 7. Antunes, D.; Oliveira, R.; Paulino, M.; et al. Severe acute asthma exacerbations under biological agents: A new therapeutic paradigm? Pulmonology 2025, 31, 2571016. DOI: https://doi.org/10.1080/25310429.2025.2571016
    8. 8. Najafi, F.; Ghasemian, N.; Safari, M.; et al. Poly(propylene imine) dendrimer as reducing agent for chloroauric acid to fabricate and stabilize gold nanoparticles. J. Phys. Chem. Solids 2021, 148, 109682. DOI: https://doi.org/10.1016/j.jpcs.2020.109682
    9. 9. Moyns, E.; Looms, J.; Jagpal, S.P.; et al. A review of cardiotoxic agent poisoning and the role of VA-ECMO as reported to the National Poisons Information Service (NPIS) 2018–2023. Toxicol. Commun. 2025, 9, 2524302. DOI: https://doi.org/10.1080/24734306.2025.2524302
    10. 10. Lam, W.; Paynter, Q.; Zhang, Z.-Q. Functional response of Amblyseius herbicolus (Acari: Phytoseiidae) on Sericothrips staphylinus (Thysanoptera: Thripidae), an ineffective biocontrol agent of gorse. Biol. Control 2021, 152, 104468. DOI: https://doi.org/10.1016/j.biocontrol.2020.104468
    11. 11. Cao, Y.; Jiang, Y.; Zhao, Y. A study on the content of integrity policies and research integrity management in Chinese universities. Front. Res. Metr. Anal. 2023, 8, 943228. DOI: https://doi.org/10.3389/frma.2023.943228
    12. 12. Vitiello, G.; Venezia, V.; Verrillo, M.; et al. Hybrid humic acid/titanium dioxide nanomaterials as highly effective antimicrobial agents against gram(−) pathogens and antibiotic contaminants in wastewater. Environ. Res. 2021, 193, 110562. DOI: https://doi.org/10.1016/j.envres.2020.110562
    13. 13. Manne, A.A.; Arigela, B.; Giduturi, A.K.; et al. Pterocarpus marsupium Roxburgh heartwood extract/chitosan nanoparticles loaded hydrogel as an innovative wound healing agent in the diabetic rat model. Mater. Today Commun. 2021, 26, 101916. DOI: https://doi.org/10.1016/j.mtcomm.2020.101916
    14. 14. Davoodi, M.; Faryadi, S.; Velni, M.J. A Graph Theoretic-Based Approach for Deploying Heterogeneous Multi-agent Systems with Application in Precision Agriculture. J. Intell. Robot. Syst. 2021, 101, 10. DOI: https://doi.org/10.1007/s10846-020-01263-4
    15. 15. Kaviarasan, B.; Kwon, O.-M.; Park, J.M.; et al. Stochastic faulty estimator-based non-fragile tracking controller for multi-agent systems with communication delay. Appl. Math. Comput. 2021, 392, 125704. DOI: https://doi.org/10.1016/j.amc.2020.125704
    16. 16. Formanek, M. Exploring the potential of large language models and generative artificial intelligence (GPT): Applications in Library and Information Science. J. Librariansh. Inf. Sci. 2025, 57, 09610006241241066. DOI: https://doi.org/10.1177/09610006241241066
    17. 17. Byun, J.H.; Jung, I.H. Phase-specific cancer-immune model considering acquired resistance to therapeutic agents. Appl. Math. Comput. 2021, 391, 125555. DOI: https://doi.org/10.1016/j.amc.2020.125555
    18. 18. Lee, Y.H.; Park, J.Y.; Lee, I.Y.; et al. Effects of cryoprotective agents and treatment methods on sperm cryopreservation of stone flounder, Kareius bicoloratus. Aquaculture 2021, 531, 735969. DOI: https://doi.org/10.1016/j.aquaculture.2020.735969
    19. 19. Silva, L.d.L.; Souza, C.d.F.; Parodi, T.V.; et al. Ethanolic extract of Hyptis mutabilis (Rich.) Briq.: An effective sedative and antioxidant agent in fish. Aquaculture 2021, 531, 735940. DOI: https://doi.org/10.1016/j.aquaculture.2020.735940
    20. 20. Cosenza, B.; Popov, N.; Juurlink, B.; et al. Easy and efficient agent-based simulations with the OpenABL language and compiler. Future Gener. Comput. Syst. 2021, 116, 61–75. DOI: https://doi.org/10.1016/j.future.2020.10.014
    21. 21. Hidayat, R.; Chowdhury, T.; Kim, Y.; et al. Density functional theory study on the reducing agents for atomic layer deposition of tungsten using tungsten chloride precursor. Appl. Surf. Sci. 2021, 538, 148156. DOI: https://doi.org/10.1016/j.apsusc.2020.148156
    22. 22. Duan, A.; Chen, M.; Lu, Q. Design of Railway Customer Service Agent Based on Large Language Model. Yangtze River Inf. Commun. 2025, 38, 86–93. DOI: https://doi.org/10.20153/j.issn.2096-9759.2025.08.024 (in Chinese)
    23. 23. Roh, D.K.; Jae, H.; Mun, H.; et al. Precise tuning of morphology and pore size of amine-functionalized MIL metal–organic frameworks using a directing agent. Mater. Sci. Eng. B 2021, 263, 114833. DOI: https://doi.org/10.1016/j.mseb.2020.114833
    24. 24. Riddle, M.E.; Tatara, E.; Olson, C.; et al. Agent-based modeling of supply disruptions in the global rare earths market. Resour. Conserv. Recycl. 2021, 164, 105193. DOI: https://doi.org/10.1016/j.resconrec.2020.105193
    25. 25. Lou, K.; Kang, A.; Xiao, P.; et al. Effects of basalt fiber coated with different sizing agents on performance and microstructures of asphalt mixture. Constr. Build. Mater. 2021, 266, 121155. DOI: https://doi.org/10.1016/j.conbuildmat.2020.121155
    26. 26. Somboon, P.; Soontorngun, N. An actin depolymerizing agent 19,20-epoxycytochalasin Q of Xylaria sp. BCC 1067 enhanced antifungal action of azole drugs through ROS-mediated cell death in yeast. Microbiol. Res. 2021, 243, 126646. DOI: https://doi.org/10.1016/j.micres.2020.126646
    27. 27. Mannekote, A.; Davies, R.; Pinto, J.D.; et al. Large language models for whole-learner support: Opportunities and challenges. Front. Artif. Intell. 2024, 7, 1460364. DOI: https://doi.org/10.3389/frai.2024.1460364
    28. 28. Lee, S.-Y.; Jang, D.-I.; Kim, D.-Y.; et al. UV laser decontamination of chemical warfare agent simulants CEPS and malathion. J. Photochem. Photobiol. A 2021, 406, 112989. DOI: https://doi.org/10.1016/j.jphotochem.2020.112989
    29. 29. Scoppa, V. Social pressure in the stadiums: Do agents change behavior without crowd support? J. Econ. Psychol. 2021, 82, 102344. DOI: https://doi.org/10.1016/j.joep.2020.102344
    30. 30. Oliveira, L.d.F.; Camargos, E.F.; Martini, L.L.L.; et al. Use of psychotropic agents to treat agitation and aggression in Brazilian patients with Alzheimer's disease: A naturalistic and multicenter study. Psychiatry Res. 2021, 295, 113591. DOI: https://doi.org/10.1016/j.psychres.2020.113591
    31. 31. Zhang, L.; Zhang, J.; Li, Y.; et al. Design of Integrated Energy System Agent Based on Reinforcement Learning. Electron. Des. Eng. 2024, 32, 145–149. DOI: https://doi.org/10.14022/j.issn1674-6236.2024.12.030 (in Chinese)
    32. 32. Yepes, A.; Ochoa-Bautista, D.; Murillo-Arango, W.; et al. Purple passion fruit seeds (Passiflora edulis f. edulis Sims) as a promising source of skin anti-aging agents: Enzymatic, antioxidant and multi-level computational studies. Arab. J. Chem. 2021, 14, 202101. DOI: https://doi.org/10.1016/j.arabjc.2020.11.011
    33. 33. Zupko, R. Application of agent-based modeling and life cycle sustainability assessment to evaluate biorefinery placement. Biomass Bioenergy 2021, 144, 105916. DOI: https://doi.org/10.1016/j.biombioe.2020.105916
    34. 34. Munjita, S.M.; Kalonda, A.; Mubemba, B.; et al. Evidence of multiple bacterial, viral, and parasitic infectious disease agents in Mastomys natalensis rodents in riverine areas in selected parts of Zambia. Infect. Ecol. Epidemiol. 2025, 15, 2441537. DOI: https://doi.org/10.1080/20008686.2024.2441537
    35. 35. Arita, T.; Namerikawa, T. Probabilistic multi-agent pose graph filtering on SE(3) via distributed ADMM and stein particle gradient descent. SICE J. Control Meas. Syst. Integr. 2025, 18, 2570573. DOI: https://doi.org/10.1080/18824889.2025.2570573
    36. 36. Sushma, K.; Lakshmi, T.N.; Arunodhayam, K.; et al. In Vitro Evaluation of Fungicides, Botanicals and Bio-control agents against Stagonosporopsis cucurbitacearum Causing Gummy Stem Blight. J. Adv. Biol. Biotechnol. 2025, 28, 1681–1691. DOI: https://doi.org/10.9734/JABB/2025/V28I123547
    37. 37. Puttasakul, T.; Sirisangwang, P.; Aroonrote, N.; et al. Optimizing Dispersion of Silver Nanoparticle Incorporated Hydrogel Matrix by Silver Ion-Reducing Agent Self-Assembly. ACS Omega 2025, 10, 62667–62674. DOI: https://doi.org/10.1021/ACSOMEGA.5C06979
    38. 38. Vendé, B.; Barberousse, A.; Ruphy, S. From 2015 to 2023, eight years of empirical research on research integrity: a scoping review. Res. Integr. Peer Rev. 2025, 10, 5. DOI: https://doi.org/10.1186/s41073-025-00163-1
    39. 39. Elayaraja, S.; Liu, G.; Zagorsek, K.; et al. TEMPO-oxidized biodegradable bacterial cellulose (BBC) membrane coated with biologically-synthesized silver nanoparticles (AgNPs) as a potential antimicrobial agent in aquaculture (In vitro). Aquaculture 2021, 530, 735746. DOI: https://doi.org/10.1016/j.aquaculture.2020.735746
    40. 40. Mahale, S.A.; Dhadse, P.; Mahale, A.; et al. In vitro assessment of copper nanoparticles gel efficacy as a futuristic drug delivery agent against periodontal pathogens. J. Taibah Univ. Sci. 2025, 19, 2549161. DOI: https://doi.org/10.1080/16583655.2025.2549161
    41. 41. Bermejo-Casado, R.; Bazaga-Fernández, I.; Carrasco-Granger, S. Law enforcement agents at European borders: perceptions of migration, and the networked and relational exercise of discretion in policy implementation. Polit. Res. Exch. 2025, 7, 2561948. DOI: https://doi.org/10.1080/2474736X.2025.2561948
    42. 42. Xu, W. Dilemmas and Countermeasures for Research Integrity Education of Graduate Students. Tianjin Sci. Technol. 2025, 52, 95–102. DOI: https://doi.org/10.14099/j.cnki.tjkj.2025.01.014 (in Chinese)
    43. 43. Nitayaphat, W.; Jintakosol, T. Sustainable Dyeing of Sugarcane Leaves-Cotton Blended Yarn with Dayak Onion (Eleutherine americana) Bulb Extract Using Eco-Friendly Mordanting Agents. J. Nat. Fibers 2025, 22, 2511998. DOI: https://doi.org/10.1080/15440478.2025.2511998
    44. 44. Sousa, N. Ethical and practical implications of AI in academic library research. J. Librariansh. Inf. Sci. 2025, 57, 03400352251391753. DOI: https://doi.org/10.1177/03400352251391753
    45. 45. Leong, H.J.-Y.; Tan, H.-D.; Teoh, M.-L. In silico discovery of skin depigmenting agents from Chlorella vulgaris: A network pharmacology and molecular simulation approach. Appl. Phycol. 2025, 6, 350–365. DOI: https://doi.org/10.1080/26388081.2025.2558516
    46. 46. Grzyb, T.; Kulczyk, S. Well-being derived from the riverscape: Linking comfort and discomfort agents. Ecosyst. People 2025, 21, 2578178. DOI: https://doi.org/10.1080/26395916.2025.2578178
    47. 47. Iwata, S.; Yamasita, N.; Asukabe, K.; et al. Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: Ewingella americana as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties. Gut Microbes 2025, 17, 2599562. DOI: https://doi.org/10.1080/19490976.2025.2599562
    48. 48. Pavlovic, A.; Rajovic, N.; Masic, S.; et al. Assessing attitudes toward research and plagiarism among medical students: A multi-site study. Res. Integr. Peer Rev. 2024, 19, 11. DOI: https://doi.org/10.1186/s13010-024-00161-z
    49. 49. Donabauer, M.; Sawall, S.; Ayx, I.; et al. Development and characterization of new contrast agents for Photon-Counting CT. Eur. J. Radiol. 2025, 195, 112643. DOI: https://doi.org/10.1016/J.EJRAD.2025.112643
    50. 50. Snellman, J.E.; Barrio, R.A.; Kaski, K.K. Social structure formation in a network of agents playing a hybrid of ultimatum and dictator games. Physica A 2021, 561, 125257. DOI: https://doi.org/10.1016/j.physa.2020.125257
    ×